摘要
目的 :探究奥曲肽联合奥美拉唑治疗上消化道出血的疗效以及对止血率、止血时间的影响。方法:选取2015年3月—2016年3月我院收治的上消化道出血患者84例为研究对象,按随机数字表法分为两组,各42例,对照组采用奥美拉唑(40 mg加入0.9%氯化钠注射液100 mL中,ivgtt,q12h)治疗;观察组在对照组基础上加用奥曲肽(100μg加入0.9%氯化钠注射液10 mL中静脉注射后,再将300μg加入0.9%氯化钠注射液48 mL中持续静脉微泵泵入,q12h)治疗,比较两组疗效。结果 :观察组总有效率为95.24%,高于对照组的78.57%,差异有统计学意义(P <0.05);观察组24 h、48 h止血率高于对照组,再出血率及平均出血时间小于对照组,差异有统计学意义(P <0.05)。结论 :奥美拉唑联合奥曲肽治疗上消化道出血的疗效显著,可缩短止血时间,提高止血率,值得临床推广。
Objective:To investigate the effcacy of octreotide combined with omeprazole in the treatment of upper gastrointestinal hemorrhage and its effect on hemostasis rate and hemostasis time.Methods:80 patients with upper gastrointestinal hemorrhage admitted to our hospital from March 2015 to March 2016 were enrolled as subjects investigated,and randomly divided into two groups,42 cases in each group.The patients in the control group were treated with omeprazole(40 mg omeprazole was added to 0.9%sodium chloride injection 100 mL,ivgtt,q12h),and the patients in the observation group were further treated with octreotide on the basis of the control group(100μg octreotide was added to 0.9%sodium chloride injection 10 mL for intravenous injection,and then 300μg octreotide was added to 0.9%sodium chloride injection 48 mL for continuous intravenous micropump pumping,q12h).The efficacy was compared between the two groups.Results:The total effective rate in the observation group was 95.24%,which was higher than 78.57%in the control group,with statistically significant difference(P<0.05).The hemostasis rate in the observation group was higher than that in the control group at 24 h and 48 h,and the rebleeding rate and mean bleeding time were lower and shorter than those in the control group,with statistically significant differences(P<0.05).Conclusion:The effcacy of omeprazole combined with octreotide in the treatment of upper gastrointestinal hemorrhage is significant,and can shorten hemostasis time and increase hemostasis rate,which is worthy of clinical promotion.
作者
祝晓蕾
Zhu Xiao-lei(Department II of Internal Medicine,Shangqiu Hospital of Traditional Chinese Medicine,Shangqiu,Henan 476000,China)
出处
《中国合理用药探索》
CAS
2019年第1期111-113,共3页
Chinese Journal of Rational Drug Use
关键词
奥曲肽
奥美拉唑
上消化道出血
止血率
止血时间
Octreotide
Omeprazole
Upper Gastrointestinal Hemorrhage
Hemostasis Rate
Hemostasis Time
