摘要
目的:探讨复方甲硝唑联合克林霉素治疗细菌性阴道炎的临床价值.方法:选取我院2017年8月—2018年12月收治的细菌性阴道炎患者110例,采用随机数字表法分为观察组和对照组,各55例.对照组采用复方甲硝唑(0.5 g,bid)治疗;观察组在对照组基础上加用克林霉素(0.3 g,bid)治疗.比较两组近期临床疗效、临床症状消失时间、白细胞介素(IL)-2、IL-6、IL-8、血清氧化应激产物及不良反应发生情况.结果:观察组临床总有效率高于对照组,差异有统计学意义(P<0.05);观察组外阴瘙痒、黏膜充血、白带异常、外阴阴道疼痛症状消失时间均短于对照组,差异有统计学意义(P<0.05);观察组治疗后IL-2、IL-6、IL-8、丙二醛水平均低于对照组,超氧化物歧化酶、一氧化氮水平均高于对照组,差异有统计学意义(P<0.05);两组无明显不良反应发生.结论:复方甲硝唑联合克林霉素治疗细菌性阴道炎的疗效理想,可改善患者的临床症状,降低炎性反应,且安全性好.
Objective:To investigate the clinical value of compound metronidazole combined with clindamycin in the treatment of bacterial vaginitis.Methods:110 patients with bacterial vaginitis admitted to our hospital from August 2017 to December 2018 were selected and randomly divided into an observation group and a control group,55 cases each.The patients in the control group were treated with compound metronidazole(0.5 g,bid),and the patients in the observation group were further treated with clindamycin(0.3 g,bid).The short-term clinical efficacy,clinical symptom disappearance time,interleukin(IL)-2,IL-6,IL-8,serum oxidative stress products and adverse reactions were compared between the two groups.Results:The total clinical effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The disappearance time of pruritus vulvae,mucosal congestion,vaginal discharge abnormality and vulvovaginal pain in the observation group was shorter than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of IL-2,IL-6,IL-8 and malondialdehyde in the observation group were lower than those in the control group,while the levels of superoxide dismutase and nitric oxide were higher than those in the control group,with statistically significant differences(P<0.05).There were no significant adverse reactions in the two groups.Conclusion:Compound metronidazole combined with clindamycin is effective in the treatment of bacterial vaginitis,which can improve the clinical symptoms of the patients and reduce inflammatory response,and has good safety.。
作者
刘辉
沈忱
Liu Hui;Shen Chen(Zhengzhou Maternal and Child Health Hospital,Zhengzhou Henan450052,China;Department of Gynecologyand Obstetrics,Yizhou District People’s Hospital,Hami Xinjiang839000,China)
出处
《中国合理用药探索》
CAS
2019年第6期175-177,182,共4页
Chinese Journal of Rational Drug Use
基金
河南省科技攻关计划项目(B20143138)
关键词
细菌性阴道炎
复方甲硝唑
克林霉素
联合治疗
Bacterial Vaginitis
Compound Metronidazole
Clindamycin
Combined Treatment
