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Multifarious diagnostic possibilities of the S100 protein family: predominantly in pediatrics and neonatology 被引量：7

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摘要 Background Numerous articles related to S100 proteins have been recently published.This review aims to introduce this large protein family and its importance in the diagnostics of many pathological conditions in children and adults.Data sources Based on original publications found in database systems,we summarize the current knowledge about the S100 protein group and highlight the most important proteins with focus on pediatric use.Results The S100 family is composed of Ca2+and Zn2+binding proteins,which are present only in vertebrates.Some of these proteins can be used as diagnostic markers in cardiology(S100A1,S100A12),oncology(S100A2,S100A5,S100A6,S100A14,S100A16,S100P,S100B),neurology(S100B),rheumatology(S100A8/A9,S100A4,S100A6,and S100A12),nephrology and infections(S100A8,S100A9,S100A8/A9,S100A12).The most useful S100 proteins in pediatrics are S100A8,S100A9,heterodimers S100A8/A9,S100B and S100A12.Conclusions The S100 family members are promising biomarkers and provide numerous possibilities for implementation into clinical practice to optimize the differential diagnostic process.
作者 Anna Medkova Josef Srovnal Jarmila Potomkova Jana Volejnikova Vladimir Mihal
机构地区 Department of Pediatrics Faculty of Medicine and Dentistry Department of Science and R esearch
出处 《World Journal of Pediatrics》 SCIE CAS CSCD 2018年第4期315-321,共7页 世界儿科杂志（英文版）
关键词 S100 DIAGNOSTICS MARKER PEDIATRICS
分类号 R73 [医药卫生—肿瘤]
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World Journal of Pediatrics
2018年 第4期

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