摘要
Objective:To investigate the effects of pre-eclampsia (PE) on blood biochemical parameters and pregnancy outcomes in patients with intrahepatic cholestasis of pregnancy (ICP). Methods: The study subjects selected 180 patients with ICP who were admitted to our hospital from January 2016 to January 2018. Among them, 45 patients with PE were marked as observation group, and the remaining 135 patients with ICP were labeled as control group. The liver function indicators, serum inflammatory factor index levels, and differences between pregnancy outcomes and neonatal outcomes were compared between the two groups.Results:The liver function indexes (ALT, AST, GGT, TBA, TBIL) in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P<0.01). The levels of serum IL-12, TNF-α and SOCS-3 in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P<0.01). The gestational weeks (36.89±0.55) of the observation group were significantly shorter than the control group (38.68±0.59), and the difference was statistically significant (t=18.56,P=0.00). The cesarean section rate and amniotic fluid rate in the observation group were observed. They were significantly higher than the control group, and the differences were statistically significant (P<0.01). The neonatal weight of the observation group (3.05±0.32) was significantly lower than that of the control group (3.39±0.45), and the difference was statistically significant (t=5.53,P=0.00). The premature birth rate, fetal distress rate, neonate in the observation group. The asphyxiation rate was significantly higher than that of the control group, and the difference was statistically significant (P<0.05).Conclusion:Preeclampsia can aggravate liver function damage and serum inflammatory factor levels in patients with intrahepatic cholestasis of pregnancy. It is an important risk factor for pregnancy outcome and neonatal outcome, and it is worthy of attention in clinical diagnosis and treatment.
