摘要
组织配型是影响肾脏移植成功和移植物长期存活的关键因素之一。目前我国各移植中心实验室组织配型技术及应用情况发展不一。为了推动肾脏移植组织配型临床诊疗的标准化,由中华医学会器官移植学分会、中国医疗保健国际交流促进会肾脏移植分会、中国医药生物技术协会移植技术分会联合发起制订了《中国肾脏移植组织配型技术临床应用指南》。本指南使用2009版牛津大学循证医学中心的证据分级与推荐强度标准对每个临床问题的证据质量和推荐强度进行分级。针对肾脏移植组织配型相关的实验室检测技术和临床应用的15个临床问题,提出了符合我国临床诊疗实践的21条推荐意见,旨在肾脏移植术前推广组织配型,提高受者和移植肾脏长期存活时间,发挥精准医学在肾脏移植领域应用价值。
Tissue matching is one of the key factors affecting the success of kidney transplantation and long-term graft survival.At present,the development of tissue matching technology and its application in the laboratory of transplant centers in China is different.In order to promote the standardization of clinical diagnosis and treatment of kidney transplantation tissue matching,the Chinese Transplantation Branch of the Chinese Medical Association,the Kidney Transplantation Branch of the China Medical Care International Exchange Promotion Association,and the Transplantation Technology Branch of the Chinese Medical Biotechnology Association jointly initiated the guidelines for clinical application of tissue matching techniques for kidney transplantation in China.This guide grades the quality of evidence and the strength of recommendation for each clinical issue using the 2009 Oxford Centre for Evidence-Based Medicine Grading and Strength of Recommendation criteria.Aiming at 15 clinical problems related to the laboratory detection technology and clinical application of kidney transplantation tissue matching,a total of 21 recommendations were put forward in line with China′s clinical diagnosis and treatment practice,aiming at promoting tissue matching before kidney transplantation,improving the long-term survival time of recipients and transplanted kidneys,and giving play to the application value of precision medicine in the field of kidney transplantation.
作者
中华医学会器官移植学分会
中国医疗保健国际交流促进会肾脏移植分会
中国医药生物技术协会移植技术分会
薛武军
郑瑾
张雷
何军
蔡俊超
刘龙山
Branch of Organ Transplantation,Chinese Medical Association;Branch of Organ Transplant Physician,Chinese Medical Doctor Association;Branch of Kidney Transplantation,China International Exchange and Promotive Association for Medical and Health Care;Xue Wujun(不详;Department of Kidney Transplantation,Hospital of Nephropathy,the First Affiliated Hospital of Xi′an Jiaotong University,Institute of Organ Transplantation,Xi′an Jiaotong University,Xi′an 710061,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2024年第27期2483-2501,共19页
National Medical Journal of China
基金
国家自然科学基金(82370755、82170768、82370802)
陕西省科技厅两链融合项目[2021LL-JB-06(3.4)]
陕西省卫生健康肾脏移植科研创新平台(2023PT-06)
白求恩公益基金会共享阳光重大疾病临床科研合作项目(G-X-2019-0101)
广东特支计划卫生健康领域领军人才项目(R09002)
关键词
肾移植
组织配型
指南
Kidney transplantation
Tissue matching
Guidelines
