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晚期及复发乳腺癌紫杉醇联合化疗35例分析 被引量:3

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摘要 目的:观察含紫杉醇的化疗方案治疗乳腺癌的疗效及不良反应。方法:所有初治病例予紫杉醇加顺铂方案,复发转移者如用过含顺铂的化疗方案且复发转移时间<6个月,改用紫杉醇加卡铂方案,余仍用紫杉醇加顺铂方案。第1天予紫杉醇135~150 mg/m2,静脉滴注3小时,第2天予顺铂70 mg/m2或卡铂AUC4~5 mg,每3~4周重复化疗。结果:随访时间2~48个月,平均13个月,带瘤生存21例,死亡14例。35例中完全缓解(CR)5例,部分缓解(PR)10例,稳定(SD)17例,进展(PD)3例,总有效率为42.8%;胸膜软组织淋巴结等处转移17例中CR 3例,PR 10例,PD 4例,有效率为76.5%。主要不良反应为白细胞下降、肌肉关节疼痛、手足麻木、脱发。结论:紫杉醇治疗乳腺癌疗效肯定,不良反应可耐受。
出处 《南通大学学报(医学版)》 2008年第3期217-,219,共2页 Journal of Nantong University(Medical sciences)
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  • 1郑秀萍,曹永峰,季顺民,丁祥珠,钱勇.紫杉醇联合顺铂治疗晚期三阴性乳腺癌18例效果观察[J].南通大学学报(医学版),2009,29(2):139-140. 被引量:6
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