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肌梗死与高血压患者心室重构机制的研究 被引量：1

Ventricular remodeling and its correlative mechanisms in patients with myocardial infarction and hypertensive patien
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摘要 ①目的探讨心肌梗死与高血压患者基质金属蛋白酶-9(MMP-9)、一氧化氮(NO)、一氧化氮合酶(NOS)、诱导型一氧化氮合酶(INOS)、高敏C-反应蛋白(HS-CRP)在心室重构中的作用。②方法本组中心肌梗死患者47例、高血压患者53例。按照心脏超声结果分为心肌梗死重构组、心肌梗死未重构组、高血压重构组和高血压未重构组,分别测定其在血清中的浓度。③结果心室重构各组MMP-9、HS-CRP数值较高,NO、NOS、INOS的较低(P<0.05或P<0.01)。随着心功能的恶化和射血分数减少,MMP-9、HS-CRP逐渐增高,而NO、NOS、INOS逐渐降低(P<0.05或P<0.01)。心肌梗死患者MMP-9、HS-CRP、NO、NOS、INOS较高血压患者高(P<0.01)。④结论MMP-9、HS-CRP可能导致心肌结构发生改变,加重心室重构。NO系统则可抑制这种变化。 Objective To explore the effects of matrixmetalloproteases-9 (MMP-9),nitric oxide(NO),nitric oxide synthase(NOS),inducible nitric oxide synthase(INOS) and high sensitive c-reaction protein(HS-CRP) in ventricular remodeling of hypertensive patients and myocardial infarction patients.Methods 47 patients with myocardial infarction and 53 hypertensive were separated into ventricular remodeling(VRM) groups and without remodeling groups by echocardiograph.The serum levels of parameters were determined.Results Ser...
作者 徐伟 孙尧 崔波
机构地区 华北煤炭医学院附属医院内五科
出处 《华北煤炭医学院学报》 2008年第3期295-297,共3页 Journal of North China Coal Medical College
关键词 心肌梗死 高血压 金属蛋白酶-9 一氧化氮 一氧化氮合酶 诱导型一氧化氮合酶 高敏C反应蛋白 心室重构 Myocardial infarction.Hypertensive.Matrixmetalloproteases-9.Nitric oxide.Nitric oxide synthase.Inducible nitric oxide synthase.High sensitive c-reaction protein.Ventricular remodeling
分类号 R542.22 [医药卫生—心血管疾病]
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参考文献2

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二级参考文献18

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共引文献7

同被引文献20

  • 1郭建中,高长青.基质金属蛋白酶及抑制剂在心肌梗死后心室重构中的作用[J].中华老年心脑血管病杂志,2005,7(1):39-42. 被引量：6
  • 2王先梅,赵连友,陈永清,武利军,黄志刚,牛晓琳.心脏肥大细胞密度在自发性高血压大鼠心肌重构中的作用[J].医学研究生学报,2005,18(B05):3-6. 被引量：1
  • 3牛占丛,段国辰,平芬,杨艳红.高血压合并冠心病患者血清基质金属蛋白酶-9的变化[J].中国老年学杂志,2007,27(10):973-974. 被引量：8
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引证文献1

华北煤炭医学院学报
2008年 第3期

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