不同麻醉方法对胃癌根治术患者围术期免疫功能的影响被引量：4

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摘要目的:探讨不同麻醉方法对胃癌根治术患者围术期白细胞介素-6(IL-6)、T淋巴细胞亚群及自然杀伤细胞(NK细胞)的影响。方法:选择胃癌根治术患者30例,随机分为两组。Ⅰ组为单纯全麻,Ⅱ组为全麻复合硬膜外麻醉。分别于麻醉前、麻醉后2h、术后1d和术后6d抽取静脉血,用放免法测定血清IL-6含量,用流式细胞仪测定T淋巴细胞亚群及NK细胞的数量。结果:两组麻醉后2hIL-6均明显升高,与麻醉前比较差异有统计学意义(P<0.05),T细胞亚群CD3+、CD4+、CD4+/CD8+、NK细胞均有所下降,与麻醉前比较,I组差异有统计学意义(P<0.05);术后1d两组IL-6均较麻醉前升高,但差异无统计学意义;T细胞亚群CD3+、CD4+、CD4+/CD8+下降与麻醉前差异有统计学意义(Ⅰ组P<0.01,Ⅱ组P<0.05);术后6d各组数据均恢复至术前水平。结论:胃癌根治术患者麻醉手术后免疫功能有一过性不同程度的抑制,其中单纯全麻组明显。全麻复合硬膜外麻醉明显轻于单纯全麻组。

作者李军李冠雄李静

机构地区榆林市第二医院

出处《实用医技杂志》 2008年第15期1988-1989,共2页 Journal of Practical Medical Techniques

关键词全麻硬膜外麻醉免疫白细胞介素-6 T淋巴细胞亚群自然杀伤细胞

分类号 R614 [医药卫生—麻醉学]

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1王世端,王士雷,江岩,徐伟.等容血液稀释自体输血对肿瘤病人围术期T淋巴细胞亚群、NK细胞影响的比较[J].中华麻醉学杂志,2001,21(9):525-527. 被引量：31

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