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急性心肌缺血是血脑钠素水平升高的独立因素 被引量：2

Acute myocardial ischemia: an independent factor for the elevation of plasma brain natriuretic peptide levels
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摘要 目的探讨急性心肌缺血是否引起血浆脑钠素(brainnatriureticpeptide,BNP)水平升高。方法回顾性分析冠心病无心力衰竭病人168例血浆BNP浓度。其中稳定型心绞痛组40例,不稳定型心绞痛组23例,急性心肌梗死组105例。另外,健康体检者为对照组88例。BNP测定采用酶联免疫吸附试验方法。结果稳定型心绞痛组血浆BNP浓度中位数42.3(7.6～491.3)ng/L,与正常对照组25.9(5.1～87.9)ng/L相比,差异有统计学意义(P=0.001)。不稳定型心绞痛组血浆BNP水平142.4(92.4～2617.7)ng/L,急性心肌梗死组126.0(5.5～3615.1)ng/L,均显著高于对照组(P=0.000)和稳定型心绞痛组(P=0.000)。不稳定型心绞痛组BNP水平显著高于急性心肌梗死组(P=0.04)。结论急性心肌缺血是血浆BNP水平升高的重要原因之一,血浆BNP水平检测可能有助于甄别急性冠状动脉综合征与稳定型冠心病。 s: Objectives To determine whether acute myocardial ischemia acts as an independent factor for the elevation of plasma brain natriuretic peptide (BNP) levels in patients with coronary heart disease (CHD). Methods A total of 168 CHD patients without symptoms of heart failure were included in this retrospective study. Among the 168 patients, 40 were with stable angina (SA group), 23 with unstable angina (UA group), and 105 with acute myocardial infarction (AMI group). Eighty-eight healthy subjects were assigned as control group. The plasma concentrations of BNP were measured by enzyme-linked immunoabsorbent assay. Results Statistically significant differences were found in median values of plasma BNP concentrations between SA group and control group [42.3(7.6～491.3)ng/L vs. 25.9(5.1～87.9)ng/L, P=0.001]. Patients with UA or with AMI had markedly increased BNP levels [142.4(92.4～2617.7)ng/L,126.0(5.5～3615.1)ng/L, respectively], compared to the healthy control people (P=0.000) and SA group (P=0.000). Moreover, BNP concentration was higher in UA patients than in AMI patients(P=0.04). Conclusions Acute myocardial ischemia might be an important factor for the elevation of plasma brain natriuretic peptide concentrations. The measurement of brain natriuretic peptide levels might be useful in discriminating patients with acute coronary syndrome and patients with stable coronary heart disease.
作者 杨阳 罗义 李广镰
机构地区 广州市第一人民医院心血管内科
出处 《岭南心血管病杂志》 2006年第5期323-325,共3页 South China Journal of Cardiovascular Diseases
基金 广州市卫生局科研基金(2004年度)
关键词 急性冠状动脉综合征 冠心病 心肌缺血 脑钠素 Acute coronary syndrome Coronary heart disease Myocardial ischemia Brain natriuretic peptide
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献9

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同被引文献30

  • 1黄昶荃,肖谦.脑钠素与糖尿病心肌病变[J].国外医学（内分泌学分册）,2005,25(2):116-118. 被引量：6
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岭南心血管病杂志
2006年 第5期

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