摘要
目的为掌握临床真菌感染及耐药性情况,指导临床抗真菌用药提供依据。方法收集2005年10月- 2006年9月医院门诊和住院患者的各类真菌培养标本1196份,用沙保罗培养基和科玛嘉显色培养基分离真菌,用“天地人”微生物半自动鉴定药敏系统鉴定菌种,用微量肉汤稀释法在“天地人”微生物半自动鉴定药敏系统中做药敏试验。结果分离出359株真菌,以白色假丝酵母菌为主,占82．5%,病房分布以重症监护(ICU)病房(23．1%)、呼吸病房(13．6%)、老年病房(6．4%)为主。耐药性最强的是灰黄霉素,耐药率达86．6%,其次为氟康唑、伊曲康唑,耐药率分别是19．2%、10．6%。两性霉素B抗菌作用最强,耐药率为0,制霉菌素、益康唑次之,耐药率分别是0．56%、0．83%。结论随着侵袭性操作和免疫受损群体的不断增多,增加了真菌感染机会,应重视真菌的耐药性监测,以指导临床合理使用抗真菌药物。
Objective To investigate the clinical fungal infection and its drug resistance,and to provide guidance for clinical use of anti-fungi drugs.Methods Altogethor 1,196 different fungi culture samples collected from both the outpa- tients and inpatients in our hospital from Oct.2005 to Sep.2006 were seperated with sabourand culture medium and CHROMagar candida color culture medium.“Tian Di Ren”half-automatic microbiological drug sensitivity identification sys- tem was applied to identify the fungus and undergo drug sensitivity test with the method of broth microdilution.Results Three hundred and fifty-nine fungi strains were isolated,the majority was candida albicans(82.5%),and was found in the ICU(23.1%),respiratory-ward(13.6%)and geriatric-ward(6.4%).The strongest drug resistance was griseofulvin, which reached up to 86.6%,followed by fluconazole(19.2%)and itraconazole( 10.6 % ).The strongest anti-fungus agent was amphotericin B,and no resistance was found,followed by nysatin(0.56%)and econazol (0.83%).Conclusion With the increased invasive procedures and immunocompromised population,the fungal infection increased.Therefore moni- toring drug resistance is very important for instructing clinical doctors to use anti-fungi drugs properly.
出处
《实用预防医学》
CAS
2006年第6期1477-1479,共3页
Practical Preventive Medicine
关键词
真菌感染
药敏试验
耐药性
分析
Fungi infection
Drug sensitivity test
Drugresistance
Analysis
