摘要
目的探讨2型糖尿病(DM)患者血管内皮细胞损伤与血白介素6(IL-6)的关系及其意义。方法检测45例2型DM患者及20例正常人外周血IL-6和循环内皮细胞(CEC)水平并进行比较。结果①2型DM患者血IL-6和CEC水平高于正常人(P<0.05);②早期糖尿病肾病患者血CEC水平明显高于单纯糖尿病患者(P<0.01);③多元逐步回归分析显示CEC与血IL-6水平和尿蛋白排泄率(UAER)显著相关,标准偏回归系数β分别为0.264(P=0.033)和0.545(P=0.000)。结论2型糖尿病血管内皮细胞损伤与体内IL-6升高有密切关系,并在糖尿病肾病的发病过程中起一定作用。
Objective To explore the clinical significance of the injury of vascular endothelial cells and elevated plasma level of inter-leukin-6 (IL-6) in patients with type 2 diabetes mellitus (DM). Methods The number of circulating endothelial cells (CEC) and plasma IL-6 level were measured in 20 normal controls(NC group) and 45 cases of type II DM, including 23 cases without albuminuria (SDM group) and 22 cases with trace albuminuria (EDN group). Results ①The CEC number and IL-6 level markedly elevated in SDM group( P < 0.05, all) and EDN group( P < 0.01, P < 0.05, respectively) than in NC group. ②The CEC number in EDN group was significantly higher than that in SDM group( P < 0.01).③Multiple stepwise regression analysis showed that there was significant positive correlation between the CEC number and plasma IL-6 level and urine albumin excretion rate(β = 0.264, P = 0.033 and /? = 0.545, P = 0.000,respectively) . Conclusion The damage of vascular endothelial cells relates to high plasma IL-6 level in the patients with type Ⅱ diabetes mellitus and pkys an important role in the development of diabetic nephropathy.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2004年第z1期160-162,共3页
Immunological Journal
关键词
内皮细胞
白介素-6
2型糖尿病
糖尿病肾病
<Keyword>dothelial cells
Interleukin-6
Type 2 diabetes mellitus
Diabetic nephropathy
