摘要
背景与目的:研究朴菇多糖的急性毒性和遗传毒性,为朴菇多糖作为饲料添加剂的安全性提供实验依据。材料与方法:采用急性经口毒性试验、Ames试验、小鼠骨髓嗜多染红细胞微核试验及小鼠精子畸形试验对朴菇多糖进行安全性评价。结果:朴菇多糖的小鼠经口LD50>10 g/kg;3项遗传毒性试验结果均为阴性。结论:在本实验条件下,朴菇多糖小鼠急性经口毒性试验属无毒级别,未见遗传毒性作用。
BACKGROUND AND AIM: To determine the acute oral toxicity and genetic toxicity of Flammulina velutipes polysaccharide.MATERIALS AND METHODS: Acute oral toxicity test,Ames test,micronucleus test of polychromatic erythrocytes in bone marrow,mice sperm shape abnormality test were used.RESULTS:The acute oral LD50 of Flammulina velutipes polysaccharide was greater than 10 g/kg in mice.The results of genetic toxicity tests were all negative.CONCLUSION: Genetic toxicity of Flammulina velutipes polysaccharide was not found,and it was classified as non-toxic agent.
出处
《癌变．畸变．突变》
CAS
CSCD
2008年第5期406-408,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
基金
科技部农业科技成果转化资金重大项目(05EFN217300418-1)
关键词
朴菇多糖
急性经口毒性
遗传毒性
Flammulina velutipes polysaccharide
acute oral toxicity
genetic toxicity
