摘要
目的探讨生脉注射液对多柔比星(阿霉素)相关性心脏毒性的保护作用。方法59例恶性肿瘤患者,随机地分成观察组和对照组两组。观察组30例,在以ADM为主的一线方案化疗前3天予生脉注射液50ml加入5%葡萄糖注射液250ml中静脉滴注,每日一次,两周一疗程;对照组29例,于化疗前3天开始服用VitE每次100mg,每日两次,辅酶Q10每次20mg,每日三次,两周一疗程。治疗前后检查心电图,超声心动图中左心室舒张末期内径(LVIDD)、左心室收缩末期内径(LVISD)、舒张早期与晚期充盈速度比值(A/E)、射血分数(EF)、短轴缩短率(FS)等各项指标。结果在本组ADM化疗后,观察组与对照组间,虽然EF差异无显著性(P>0.05),但心电图异常改变及LVIDD、LVISD、A/E、EF、FS的差异有显著性(P<0.05)。结论生脉注射液是预防和减轻ADM引起的急性心脏毒性的较为理想的药物,对慢性心脏毒性发生的减轻也有益。
Purpose:To evaluate the protection of astragalus injection for doxombicin(adriamycin)-associated cardio-toxicity,Methods:59 patients were randomized into two groups for this clinical trial.30 patients were in the test group,and 29 in control group.Patients in the test group received sheng mai injection in 5% glucose solution once every day for two weeds starting three days before adriarnycin-based chemotherapy.29 patients in the control group began to receive oral vitamin E 100 mg twice a day and coenzyme Q10 20 mg three times a day for two weeks.Chemotherapy is the same as that in the test group.Electrocardionram(ECG)and echocardiogram were employed to evaluate the cardiac function.Results:There was a substantial difference in ejection fracton between the two groups,but the difference was not statistically signifi-cant.Statistically significant differences were observed in the two groups with regard to all other parameters,including abnormal changes in ECG and LVIDD,LVISD,A/E,EF,FS.Conclusions:shengmai injection is a good drug which can prevent the occurrence of acute cardxotosicity associated with adriamycin.It can also reduce the occurrence of chronic cardiotoxicity.
出处
《中国医药指南》
2008年第15期203-205,共3页
Guide of China Medicine
关键词
生脉注射液
多柔比星
心脏毒性
shengmai injection
doxorubicin
cardiotoxicity
