摘要
目的:探讨行经皮冠状动脉介入(PCI)治疗的不稳定性心绞痛患者术前血浆妊娠相关血浆蛋白A(PAPP-A)水平对术后高敏C反应蛋白(hs-CRP)和肌钙蛋白(CTnI)的影响。方法:155例择期行经皮冠状动脉介入治疗的不稳定心绞痛患者,根据手术前24hPAPP-A是否升高(PAPP-A≥10mIU/L)分为高PAPP-A组(57例,PAPP-A≥10mIU/L)和低PAPP组(98例,PAPP-A<10mIU/L)。分别检测术后24h内hs-CRP水平及cTnI阳性率,并进行两组间各观察指标的比较。结果:高PAPP-A组术后hs-CRP水平及cTnI阳性率均明显高于低PAPP-A组(P<0.05)。术前PAPP-A含量与术后hs-CRP水平呈显著正相关。Logistic回归分析表明术前血浆PAPP-A水平是术后cTnI阳性的独立预测指标(P<0.05)。结论:冠状动脉介入治疗术前血PAPP-A含量与术后hs-CRP成正相关,是术后炎症反应及心肌损伤的独立预测因素。
Objective:To study the effects of Pregnancy Associated Plasma Protein A on high sensitivity C Reactive Protein(hs-CRP)and Troponin I(cTnI)in unstable angina patients after percutaneous coronary intervention(PCI).Methods :According to whether Pregnancy Associated Plasma Protein A(PAPP-A)≥10mIU/L or not,patients were divided into high PAPP-A group and low PAPP-Agroup before PCI.The serum high sensitivity C Reactive Protein(hs-CRP)and Troponin I(cTnI)levels were measured within 24 hours after PCI,and the compa...
出处
《陕西医学杂志》
CAS
北大核心
2008年第12期1611-1613,1658,共4页
Shaanxi Medical Journal
基金
河北省科技厅重大项目(06276107D)
河北省教委博士基金(B2004126)
河北省卫生厅重点跟踪项目(0413)
