摘要
目的探讨孕妇血浆血管性假血友病因子(vWF)及血栓调节蛋白(TM)水平变化与妊娠高血压综合征(PIH)发病的关系。方法应用酶联免疫吸附试验(ELISA)分别测定38例PIH患者(PIH组)及16例正常妊娠妇女(正常妊娠组)血浆中vWF及TM水平,并以20名健康未孕妇女(正常未孕组)为对照。结果正常妊娠组vWF(95.4±40.2)%,轻度PIH患者血浆vWF为(98.1±41.1)%。二者比较,无显著性差异(P>0.05);正常妊娠组TM为(13.7±4.6)ng/mL,轻度PIH患者为(17.4±7.1)ng/mL,二者比较,有显著性差异(P<0.05)。中、重度PIH患者血浆vWF为(195.6±39.8)%,TM为(21.8±7.4)ng/mL,与正常妊娠组比较,有显著性差异(P<0.01)。PIH患者血浆vWF与TM呈显著正相关。结论vWF和TM可作为判断PIH病情程度的指标;vWF与TM在PIH发病中起相互协同作用。
Objective To study the association of plasma von Willebrand factor(vWF) and thrombomodulin(TM) levels in patients with pregnancy induced hypertension(PIH).Methods Plasma vWF and TM were studied by ELISA method in 38 patients with PIH,16 normal pregnant women and 20 normal non-pregnant women.Results Circulation levels of vWF and TM were increased with increasing severity of the PIH.In mild PIH patients,the levels of plasma vWF(98.1± 41.1)% weren’t significantly higher than those in heathy pregnant women[(95....
出处
《中国血液流变学杂志》
CAS
2008年第4期580-581,596,共3页
Chinese Journal of Hemorheology
