5EASL, International Consensus Conference on Hepatitis C. Consensus statement[J]. J. Hepatolosy, 1999,31 (Suppl.) : 3-8
6Chomczynskl P, Sncchi N, Single - step method of RNA isolation byguanidinium hiocyanate - phenol - chloroform extraction [J]. AnalBiochem.1978, 162:156.
7Ginabreda MG, Yoshida CF, Niel C.Genomic characterization of Brazilian hepatitis C virus genotypes 1a and 1b[J]. Braz J Med Biol Res, 1997,30(3) :339 - 345.
8Wang, Y., H. Okamoto, F. Tsuda et al. 1993 Prevalence, genotypes and an isolate (HC - C2) of hepatitis C virus inChinese patients with liver disease[J]. J. Med, Virol. 40:254-260.
9YONG YUAN ZHANG, ANNA S. F. LOK,DANIEL T. M. Greater Diversity of Hepatitis C Virus C, enotypes Found in Hong Kong than in China's Mainland[J].JOURNAL OF CLINICAL MICROBIOLOGY, Nov. 1995, 2931-2934.
10Nakaraura H, Ogawa H, Kureda T.et al. Interferon treatment for patients with chronic hepatitis C infected with high viral load of genotype 2 virus[J]. Hepatogastroenterology,2002 Sep-Oct.49(47):1373-1376.
2Collins JF, Wesssling - Resnick M, Knutson MD. Hepcidin regula- tion of iron transport[J]. J Nutr, 2008, 138(11 ) : 2284 -2288.
3Fujita N, Sugimoto RN, Araki J, et al. Hepatic iron accumulation is associated with disease progression and resistance to interferon/ ribavirin combination therapy in chornic hepatitis C [ J]. J Gastro- enterol Hepatol, 2007, 22( 11 ) : 1886 - 1893.
4Nemeth E, Turtle MS, Powelson J, et al. Hepcidin regulates cellu- lar iron ellux by binding to ferroportin and inducing its intemaliza-tion[J]. Science, 2004, 306(5704): 2090-2093.
5Georgopoulou U, Dimitriadis A, Foka 17, et al. Hepcidin and the iron enigna in HCV infection[J ]. Virulence, 2014, 5(4) : 465 -476.
6Fujita N, Sugimoto R, Takeo M, et al. Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C [ J ]. Mol Med, 2007, 13(1/2) : 97 - 104.
7Liu HY, Trinh TL, Dong HJ, et al. Iron regulator hepcidin exhib- its antiviral against hepatitis C virus[ J]. PLoS ONE, 2012, 7 (10) : e46631.
8Pietrangelo A, Dierssen U, Vallil L, et al. STAT3 is required for IL -6 - gpl30 - dependent action of hepcidin in vivo[ J]. Gastro- enterology, 2007, 132( 1 ): 294-300.
9Marrero JA, Scrag HB. Alpha-fetoprotein should be included in the hepatocellular careinoma surveillanee guidelines of the ameri- can association for the study of liver diseases [J]. Hepatology, 2011,53(3) : 1060.
