摘要
目的:观察双黄连微乳剂的抗炎作用及其途径。方法:采用角叉菜胶诱导大鼠胸膜炎模型。双黄连各组分别给予双黄连口服液30 g.kg-1;双黄连微乳1高、低剂量组分别给予30,15 g.kg-1;双黄连微乳2高、低剂量组分别给予30,15 g.kg-1;阿司匹林组给予阿司匹林0.3 g.kg-1;正常组和模型组给予等体积蒸馏水。均灌胃给药,连续6 d,每日2次。于第5天给药后30 min造模,造模18 h后取胸腔渗出液,检测其胸腔渗出液中肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)、前列腺素E2(PGE2)和蛋白质(pro)含量。结果:模型组大鼠胸腔渗出液中TNF-α,IL-8,PGE2和pro含量显著升高(TNF-α和IL-8P<0.01,PGE2和ProP<0.05);与模型组相比,给药各组均可显著降低大鼠胸腔渗出液中TNF,PGE2含量(微乳1,2高剂量组P<0.01),但对IL-8和pro含量的抑制作用均不显著。结论:双黄连微乳剂具有抗炎作用,其作用机制可能与减少炎症因子的渗出、干预花生四烯酸(AA)代谢有关。
Objective:To explore the anti-inflammatory effect and possible mechanism of Shuang-huang-lian(SHL) microemulsion.Method:Rat model of pleuritis was established by thoracic injecting 0.2 mL of 1% carrageenan.Rats in the treated groups were orally administered with SHL microemulsion prescription 1,2,and oral liquid,while those in the positive control group were given aspirin.Rats in the normal group and the model group were given equal volume of water.Each groups were given their medicine for successive 6 days...
出处
《中国中药杂志》
CAS
CSCD
北大核心
2009年第6期744-747,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(30472195)
关键词
双黄连微乳
抗炎
细胞因子
TNF-
αPGE2
胸膜炎模型大鼠
Shuang-huang-lian（SHL） microemulsion
anti-inflammatory effect
cytokine
TNF-α
PGE2
rat model of pleuritis
