摘要
目的探讨银杏注射液对原发性肾病综合征(PNS)患儿高凝状态的影响。方法对26例PNS患儿使用银杏注射液加速尿治疗,观察其治疗前后的尿量、体重,并测定其治疗前后血液流变学指标、血小板聚集功能、纤溶活性等指标。结果PNS患儿经用银杏注射液加速尿治疗后较治疗前尿量明显增加,体重明显下降(P<0.05),治疗后尿量、体重与对照组比较差异也有显著性(P<0.05);血浆粘度、全血粘度(高切、低切)、红细胞聚集指数、纤维蛋白原、血小板聚集率治疗后较治疗前明显降低(P<0.05),治疗后与对照组比较差异有显著性(P<0.05);活化部分凝血活酶时间(APTT)、血浆凝血酶时间(TT)、血浆纤维蛋白原降解物(FDP)、血浆D-二聚体(DD)等纤溶指标治疗前后无明显变化(P>0.05),与对照组相比差异无显著性(P>0.05)。结论银杏注射液和速尿联合治疗PNS,既可达到利尿消肿的目的,又有降低高凝状态的作用。
Objective To observe the effect of Ginkgo injection on hypercoagulability in primary nephrotic syndrome(PNS) of children.Methods Treatment group(n=26) with PNS were treated with Ginkgo injection plus furosemide in addition to conventional therapy,and their 24-hour urine volume,body weight,hemorheology,platelet aggregation and fibrinolytic indexes(APTT,TT,FDP and DD)were observed and measured.Control group(n=20) accepted conventional therapy.Results There was obvious increase of 24-hour urine volume and significant decrease of body weight in treatment group(P<0.05)after therapy,there was obvious differences in urine volume and body weight compared to control group.Hemorheology and platelet aggregation,showed dramatic drop in treatment group(P<0.05) after therapy.There were no statistical differences in fibrinolytic indexes between two groups(P>0.05).Conclusion Combined therapy 0f Ginkgo and furosemide in PNS not only had diuretic function but also had anticoagulant effect.
出处
《吉林医药学院学报》
2007年第2期80-82,共3页
Journal of Jilin Medical University
