摘要
局灶性脑缺血动物模型在探讨脑血管病的病理生理变化、发病机制及其防治的研究有重要意义。本文概述了开颅物理阻断血流的方法、微栓子栓塞法、线栓法、脑血栓形成动物模型的建立方法、内皮素灌注诱导血管收缩法等模型制作方法等建立局灶性脑缺血动物模型的基本原理及优缺点。
The animal model of focal cerebral ischemia plays an important role in the investigation of pathophysiology,pathogenesis,prevention and treatment in cerebrovascular disease.This article analyzed the methods for making model of focal cerebral ischemia and explained the basic principle and merits and demerits of these methods including opening skull to physically block the blood,embolization,suture-occluded,cerebral thrombosis,endothelin-induced vasoconstriction,and so on.
出处
《中国卒中杂志》
2008年第8期603-607,共5页
Chinese Journal of Stroke
关键词
动物模型
方法
脑缺血
Animal model
Method
Cerebral ischemia
