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较低剂量地高辛与追加西地兰治疗心衰的研究 被引量:5

较低剂量地高辛与追加西地兰治疗心衰的研究
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摘要 目的 探讨较低剂量地高辛与适时追加西地兰治疗充血性心力衰竭(CHF)的疗效及中毒反应.方法 采用临床对照分析将86例CHF随机分成2组,治疗组44例,较低剂量地高辛维持,适时追加西地兰;对照组:用地高辛加氢氯噻嗪.结果 治疗组的疗效明显优于对照组,中毒反应发生率为6.8%和4.8%,明显低于传统负荷疗法中毒反应率的25%.结论 本疗法由于有效率明显优于对照组,而且中毒反应明显低于传统疗法,因而认为,较低剂量地高辛适时追加西地兰疗法不失为治疗CHF的理想方案.同时显示:较低剂量地高辛(0.125~0.25 mg)治疗心衰(CHF),能改善病人的左室功能,又能纠正神经内分泌异常,安全而有效,此点在临床上具有重要意义. Objective West a discussion lower dosage digoxin with at the right moment supplements the treatment congested heart failure (CHF)the curative effect and is poisoned the response. Method Uses the clinical check analysis stochastically to divide into 86 examples CHF two groups, the treatment group 44 examples. West a lover dosage digo xin maintonance west, at the right moment supplements blue; Control group: With digoxin hydrogenation chlorine sai qin. Result Treatment group's curative effect surpasses the control group obviously, the poison responded the formation rate is 6.8% and 4.8%, Is lower than the traditional load therapy poison reaction reactivity rate obviously 25%. Conclusion Because this therapy effectiveness surpasses the control group obviously, moreover the toxicant response is lower than the traditional therapy obviously, thus believed west, West a lower dosage digoxin at the right moment supplements the blue therapy not to lose for treats CHF the ideal plan. Also demonstrated that: A lover dosage digoxin (0.125~0.25 mg) treats the heart to fade (CHF),Can improve patient's left room function. Also can correct the nerve cryptorrhea, safe and is effective ,this in on clinical has the vital significance.
出处 《中国实用医药》 2007年第12期21-22,共2页 China Practical Medicine
关键词 较低剂量地高辛 追加西地兰 充血性心力衰竭 West a lower dosege digoxin West supplement blue Congested heart failure
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  • 1[1]The digitals investcgation Group.The effect of digoxin on mortality and morbility in patients with heart failure.N EngL J Med,1997,336:525-533.
  • 2何厚琦,蒋贤.地高辛维持量疗法是降低洋地黄中毒发生率的较佳方法[J].中国急救医学,1984,(4):198.
  • 3[3]Farghi R.Ventricular rate Lontral in chronic atrial fibrillation during daily activity and programmed exercise:a crossover opne-Label study of five drug regimens.J Am coll cardiol,1999,33:304-310.

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