摘要
目的观察西沙必利加阿普唑仑联合治疗便秘型肠易激综合征的疗效。方法按罗马Ⅱ标准选择的43例具有精神障碍的便秘型IBS患者分为2组:治疗组22例,予西沙必利5mg/次,3次/d,加阿普唑仑0.4mg/次,2次/d,及1次/睡前;对照组23例单用西沙必利,用法同治疗组。2组疗程均为4周。结果治疗组治疗后的症状总积分为170分,平均(7.73±5.28)分;西沙必利组治疗后的症状总积分为350分,平均(16.67±8.99)分。2组经治疗后平均积分比较差异有显著性(t=4.566,P<0.001)。2组的总有效率比较,差异有显著性(χ2=6.484,P<0.05)。结论西沙必利加阿普唑仑联合治疗便秘型肠易激综合征可明显改善便秘型IBS患者的便秘、腹痛、腹胀等症状,效果优于单用西沙必利。
objective To observe the clinical efficacy of Cisapride combined Alprazolam in the treatment of Constipation-Predominant Irritable Bowel Syndrome. Methods 43 patients with psychonosema were sellected according to the standart of Rome II and randomized into two groups: treatment group in which 22 cases were treated with Cisapride combined Alprazolam and control group in which 23 cases were treated with Cisapride only. Results The total scores after treatment was 170 and average scores was 7.73±5.28 in treatment group;The total scores after treatment was 350 and average scores was 16.67±8.99 in control group. There was remarkble statistical difference in average score before treatment between two group(t=4.566,P<0.001). The total effective rates in treatment group was higher than that of control(χ2=6.484,P<0.05). Conclusions Clinical manifestation of constipation, stomachache and abdominal distension can be improved by Cisapride combined Alprazolam on the therapy for Constipation- Predominant Irritable Bowel Syndrome., the clinical efficacy was superior to that of Cisapride.
出处
《中国医药导报》
CAS
2006年第20期15-16,共2页
China Medical Herald
