摘要
目的 探讨妇科恶性肿瘤患者化疗后发生糖尿病与化疗的关系。方法 采用回顾性分析方法对我院1990年1月至2001年10月收治化疗后发生糖尿病18例妇科肿瘤患者(A组)的化疗的年龄、化疗方案、肿瘤类型及化疗中肝功能、电解质异常情况进行总结,并对其疾病转归进行随访,并与同期化疗且化疗前患糖尿病67例(B组)相比较。结果A组以卵巢恶性肿瘤为主,部分患者化疗结束后糖尿病可缓解;B组以子宫内膜癌为主,部分患者化疗中糖尿病加重,化疗结束后减轻。两者疾病构成比差异有显著性。结论化疗可能对胰腺有影响而诱发糖尿病,应引起重视。
Objective To explore the relationship between chemotherapy and diabetes mellitus among patients with gynecological malignant tumors. Methods Retrospectively analyzed characteristics of 18 patients with gynecological malignant tumor who entered our hospital during 1990.1 to 2001.10 and were diagnosed diabetes mellitus after chemotherapy (DMA), including type and stage of tumor, age, chemotherapy regimen, abnormal in hepatic function, 'change in electrolytic balance and outcomes followed -up . Compared with other 6 7 cases in whom diabetes mellitus was diagnosed before chemotherapy ( DMB ) . Results Most patients were ovarian carcinoma in DMA group, but most cases in DMB group were endometral carcinoma; In some cases of DMA group, their diabetes mellitus could be relieved or cured, but in DMB group, only a few cases could be relieved, none of them got cured. There were significant deference between the two groups. Conclusion It should be emphasized that chemotherapy may have toxicity to insular function, and can induce diabetes mellitus.
出处
《中国妇产科临床杂志》
2002年第1期13-15,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
关键词
恶性肿瘤
化学治疗
糖尿病
Malignant tumor
Chemotherapy
Diabetes Mellitus
