摘要
目的:观察培哚普利治疗慢性充血性心力衰竭(CHF)的临床疗效。方法:经常规利尿剂、血管扩张剂、洋地黄类药物治疗效果欠佳的42例CHF患者,给予口服培哚普利2mg/d～4mg/d,治疗2～3个月,观察治疗前后心率、心胸比、血压、左室舒张末期内径、左室射血分数及心功能变化。结果:治疗后心率、血压、心胸比及左室舒张末期内径与治疗前比较均明显下降(P<0.05、P<0.01),心功能改善1级～2级,药物副作用少,患者耐受性好。结论:培哚普利治疗CHF疗效好,可以作为CHF的基本治疗药物之一。
Objective: To observe the effect of perindopril in treating patients with chronic congestive heart failure. Methods: Forty-two patients,who had unsatisfactory results under conventional diuretics,vasodilators therapy,digitals,were given perindopril (ACEI)2mg-4mg orally once a day for 2～3 months。The changes of heart rate(HR), blood pressure(BP), cardiothoracic ratio, left ventricular end diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF) and cardiac function (NYHA ) were observed. Results:After 2～3 months therapy,HR,BP, cardiothoracic ratio and LVEDD all decreased significanly (P<0.05,P<0.01; cardiac function (NYHA)improved 1 grade-2 grade.Perindopril had few adverse effects and patients' tolerance was perfect. Conclusion:The effect of perindopril in treating patients with chronic congestive heart failure is satisfactory. It has few adverse effects. It will be one of basic medicine for treating patients with CHF.
出处
《中国药物应用与监测》
CAS
2004年第4期23-24,共2页
Chinese Journal of Drug Application and Monitoring
关键词
心力衰竭
培哚普利
血管紧张素转换酶抑制剂
Heart failure
Perindopfil
Angiotensin Conversion Enzyme Inbibitor(ACEI)
