摘要
激光打孔是一种精度高、操作简便的材料表面修饰物理手段。以往研究曾使用准分子和飞秒级钛宝石激光器作为打孔光源。为了验证脉冲 Nd:YAG 激光器对组织工程材料打孔的效果,掌握不同激光光束特性和能量的成孔规律,对组织工程薄层生物材料激光打孔进行了实验研究。选用能量输出范围为0.01～1J 的脉冲 Nd:YAG 激光器和厚约50 μm的片状聚氨酯材料(PU)进行打孔。改变激光输出能量、脉冲宽度、光阑孔径和光斑模式,用显微镜观察不同条件的穿孔形态。当 Nd:YAG 激光器脉冲宽度为30μs,入射能量密度为0.6×10~4～2.1×10~4J/cm^2时可击穿厚为50 μm的 PU 材料,成孔直径在20～90μm之间,且低阶模光束成孔边缘光滑,对周围材料影响小。低阶模的穿孔直径为20～40μm,高阶模的穿孔直径为60～90μm。实验结果表明脉冲 Nd:YAG 激光器可以用作组织工程血管材料打孔。
Laser perforation is a means of physical surface modification that is precise and easy to operate.There was much study used excimer laser and femtosecod Ti-sapphire laser as source of perforation.This experiment was taken to verify the effect of laser perforation on the lamina matrixes and to master the relation and regulation between the pattern of the perforation and the parameters.It took a pulsed Nd:YAG laser which outputs 0.01～1 J and lamellar PU matrix which was about 50μm in thickness.Change output energy,pulse duration,diameter of the diaphragm and laser mode and compare difference of appearance of the holes.The results were examined under a microscope.When the pulse-width was 30 μs and the energy density was 0.6×10~4～2.1×10~4 J/cm^2 the beam could drill through PU and made 20～90μm perforation,further more,the low order mode beam brought less heat impact than the other.The low order mode created 20～40 μm perforation the higher-order mode created 60～90 μm perforation.Pulse Nd:YAG laser can perforate the tissue engineering blood vessel matrix.
出处
《红外与激光工程》
EI
CSCD
北大核心
2006年第z3期405-409,共5页
Infrared and Laser Engineering
