摘要
目的观察螺内酯对高血压病患者血管内皮功能的影响及其降压治疗效果。方法60例高血压病患者随机分为二组常规治疗组30例,采用非洛地平、培多普利治疗4w;螺内酯治疗组30例,在非洛地平、培多普利治疗基础上加用螺内酯联合治疗4w,观察二组血清一氧化氮(NO)和过氧化氢酶(CAT)的改变及降压效果。结果经上述治疗后,二组高血压患者的血清NO及CAT均有升高,血压亦明显下降,其中,以螺内酯治疗组NO、CAT升高更为显著(P<0.01),降压幅度更加明显(P<0.05)。结论高血压患者采用螺内酯联合治疗,可能更有利于改善患者的血管内皮功能,增强降压效果。
Objective To observe the clinical healing effect of spironolactone and its effect to plasma vasoactive substances in pertinacity hypertension.Methods The 60 patients were divided into 2 group,the routine and the spironolactone group,which were treated by Felodipine and Perindopril.At the same time,we added Spironolactone to the spironolactone group.Before after 4 weeks,we measured the blood pressure and the level of No and CAT.Results After 4 weeks,the blood pressure both reduced,but the level of spironolac...
出处
《湖南师范大学学报（医学版）》
2005年第2期16-18,共3页
Journal of Hunan Normal University(Medical Sciences)
