摘要
探讨不稳定斑块形成、斑块破裂及急性冠状动脉综合征发生的机制对临床防治急性冠状动脉综合征有重要的指导意义。研究证实血凝素样氧化低密度脂蛋白受体-1作为氧化低密度脂蛋白的主要受体,介导了氧化低密度脂蛋白诱导的细胞凋亡、炎症反应、基质降解及血栓形成等过程,血凝素样氧化低密度脂蛋白受体-1表达增加会引起纤维帽变薄、脂核增大、斑块不稳定及破裂,最终导致急性冠状动脉综合征的发生。
It is important to study the mechanisms for forming unstable plaque,the disruption of plaque,and the development of acute coronary syndrome.Studies have shown that lectin-like oxidized low-density lipoprotein receptor-1(LOX-1) is involve in apoptosis,the inflammatory reaction,degradation of matrix,and development of thrombus stimulated by oxidized low-density lipoprotein.With an increase in the expression of LOX-1 a chain reaction is provoked attenuation of plaque cap,instability and disruption of the plaqu...
出处
《心血管病学进展》
CAS
2009年第6期1009-1012,共4页
Advances in Cardiovascular Diseases
基金
河北省卫生厅医学科学研究重点课题(编号:08016)
