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老年2型糖尿病患者肝、肾功能对胰岛功能评估的影响 被引量：3

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摘要 目的探讨肝、肾功能对老年2型糖尿病患者胰岛功能评估的影响。方法对老(269例)、中(254例)、青年(93例)三组患者肝、肾及胰岛功能相关指标进行观察和统计分析。结果老年组糖尿病肾病(DN)及慢性肾损害(CKD)发生率较高,与中、青年组比较有差异有统计学意义(P<0.05)。相关分析显示,DN及尿白蛋白排泄率(UAER)与C肽(C-P)及胰岛素(INS)曲线下面积有显著的相关关系(P<0.05)。回归分析显示,DN与C-P曲线下面积有显著的相关关系(P<0.05)。结论肾功能减退会造成C-P及INS的蓄积,此时C-P及INS浓度的增加并不代表胰岛分泌功能增强。老年2型糖尿病患者DN及CKD发生率较高,应注意肾功能减退对胰岛功能评估的影响。
作者 李铭 张丽娜 牟忠卿 鲜彤章 周雁 于冬妮 王晓霞 潘琦 郭立新
机构地区 卫生部北京医院内分泌科
出处 《中华临床医师杂志（电子版）》 CAS 2010年第5期661-663,共3页 Chinese Journal of Clinicians(Electronic Edition)
关键词 糖尿病 2型 老年人 胰岛功能 肾功能减退
分类号 R587.1 [医药卫生—内分泌]
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  • 1张路霞,王梅,王海燕.慢性肾脏病的流行病学研究[J].中华肾脏病杂志,2005,21(7):425-428. 被引量：69
  • 2Xue JL,Ma JZ,Louis TA,et al.Forecast of the number of patients with end-stage renal disease in the United States to the year 2010.J Am Soc Nephrol,2001,12:2753-2758.
  • 3Coresh J,Astor BC,Green T,et al.Prevalence of Chronic Kidney Disease and Decreased Kidney Function in the Adult US Population:Third National Health and Nutrition Examination Survey.Am J Kidney Dis,2003,41:1-12.
  • 4Chobanian AV,Bakris GL,Black HR,et al.The Seventh Report of the Joint National Committee on prevention,detection,evaluation and treatment of high blood pressure.JAMA,2003,21:2560-2572.
  • 5Anonymous.KDOQI clinical practice guidelines for chronic kidney disease:evaluation,classification,and stratification.Kidney Disease Outcome Quality Initiative.Am J Kidney Dis,2002,39 Suppl 2:S1-S246.
  • 6Chadban SJ,Briganti EM,Kerr PG,et al.Prevalence of kidney damage in Australian adults:the AusDiab kidney study.J Am Soc Nephrol,2003,14:S131-S138.
  • 7Garg AX,Kiberd BA,Clark WF,et al.Albuminuria and renal insufficiency prevalence guides population screening:results form the NHANESⅢ.Kidney Int,2002,61:2165-2175.
  • 8Ramirez SP,Mcclellan W,Port FK,et al.Risk factors for proteinuria in a large,multiracial,southeast Asian population.J Am Soc Nephrol,2002,13:1907-1917.
  • 9Levey AS,Eckardt KU,Tsukamoto Y,et al.Definition and classification of chronic kidney disease:a position statement from Kidney Disease:Improving Global Outcomes (KDIGO).Kidney Int,2005,67:2089-2100.
  • 10Zuo L,Ma YCH,Wang M,et al.Application of glomerular giltration rate estimating euqtions in Chinese patients with chronic kidney disease.Am J Kidney Dis,2005,45:463-472.

共引文献477

同被引文献26

  • 1姜丽娟.老年糖尿病患者低血糖反应首发症状观察与护理[J].实用临床医药杂志（护理版）,2007,3(2):7-8. 被引量：8
  • 2Alberti KG, Zimmet PZ. Definition, diagnosis and classificaion of diabetes mellitas and its complications. Partl: diagnoses and classi- fication of diabetes mellitus. Provisional report of a WHO Consulta- tion [J]. Diabet Med, 1998, 15(7): 539-553.
  • 3蔡美琴 沈秀华 王少墨.糖尿病患者的营养状况及影响血糖控制的非药物因索分析.卫生研究,2002,:31-40,38.
  • 4中华医学会糖尿病学分会,中国医师协会营养医师专业委员会.中国糖尿病医学营养治疗指南[S].2010:8.
  • 5Manders RI, Koopman R, Beelen M. The muscle protein synthetic response to carbohydrate and protein ingestion is not impaired in men with longstanding type 2 diabetes [J]. J Nutr, 2008, 138(6): 1079-1085.
  • 6Emma Wilmot,IskandarIdris. Early onset type 2 diabetes: risk factors, clinical impact and management[J]. Therapeu- tic Advances in Chronic Disease, 2014,5 (6) : 234-244.
  • 7Berkowitz SA, Meigs JB, Wexler DJ. Age at type 2 diabetes onset and glycaemic control:results from the National health and Nutrition Examination Survey(NHANES)2005- 2010[J]. Diabetologia,2013,56(9) :2593-2600.
  • 8Holman RR, Paul SK, Bethel MA, et al. 10-year follow-up of intensive glucose control in type 2 diabetes[J]. N Engl J Med, 2008,359(9) : 1577-1589.
  • 9White NH, Sun W, Cleary PA, et al. Prolonged effect of in- tensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial[J]. Arch Ophthal- mol, 2008,126(12) : 1707-1715.
  • 10Levey AS,Bosch JP,Lewis JB,et al. A more accurate method to estimate glomerular filtration rate from serum creatinine : a new prediction equation[J]. Ann Intern Med, 1999,130(6) :461-470.

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中华临床医师杂志（电子版）
2010年 第5期

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