摘要
目的探讨幽门螺杆菌(Hp)感染与脑梗死的关系。方法用尿素14C呼气试验在150例脑梗死患者及150例对照者中检测Hp感染情况。同时检测两组人群的颈动脉粥样硬化斑块数目和性质、颈动脉内径、血脂及血黏度。结果脑梗死者Hp阳性84例,阳性率56.0%;对照组Hp阳性38例,阳性率25.3%,两组差异有统计学意义(P<0.01)。调整常见危险因素后,Hp感染仍增加脑梗死的危险性(OR=3.295,95%CI1.603～6.774)。脑梗死者的颈动脉粥样硬化斑块发生率为78.7%(118/150),对照组为32.0%(48/150);两组间显著有统计学差异(P<0.01)。脑梗死者在颈动脉内膜-中层厚度(IMT)、内径、血脂水平(总胆固醇、三酰甘油)及血黏度方面均与对照组存在显著差异(P均<0.01)。结论脑梗死患者有高发的Hp感染,其致病机理可能是影响了动脉粥样硬化的发生。
Objective To study the relationship between Helicobacter pylori (Hp) infection and ischemic stroke. Methods One hundred and fifty patients with ischemic stroke and 150 normal healthy controls underwent 14C-Urea Breath Test to determine Hp infection. The numbers and the nature of carotid atherosclerotic plaque and inner diameter of carotid artery were assessed by Doppler ultrasonography. Also, their plasma lipids and blood viscosity were measured. Results The Hp infection rate in the stroke group was 56.0% (...
出处
《神经病学与神经康复学杂志》
2009年第3期187-190,共4页
Journal of Neurology and Neurorehabilitation
关键词
脑梗死
幽门螺杆菌
颈动脉粥样硬化
ischemic stroke
Helicobacter pylori
carotid atherosclerosis
