摘要
目的探讨幽门螺杆菌(Hp)与消化性溃疡穿孔、出血、幽门狭窄的关系,为临床治疗提供依据。方法随机选择96例因胃十二指肠溃疡穿孔、出血、幽门狭窄而急诊手术的病人,于胃穿部手术标本或活检标本,作免疫组化染色,在高倍镜下行Hp计数,对Hp感染的密度进行分析,按Rauws标准评估胃炎的严重度。结果消化性溃疡穿孔、出血、幽门狭窄的Hp感染阳性率分别为90%、58%、50%;Hp感染分级分别为3郾4±0郾19、2郾2±0郾17、2郾6±0郾20;Rauws分数分别为8郾0±0郾31、5郾1±0郾29、5郾8±0郾42。Hp感染和胃炎改变在消化性溃疡穿孔较出血,狭窄更为明显,前者的P值分别为<0郾01和<0郾05。结论消化性溃疡穿孔与Hp感染密切相关,根治Hp能有效防止溃疡穿孔。
Objective To study the relationship between the Helicobacter pylori(Hp)and perforation,bleeding of peptic ulcer and pyloristenosis.Methods Randomized sele c tion of96patients with perforation,bleeding of peptic ulcer and pyloristenosis underwent emergency operation.Detection of Hp was carried out in the resected specimens or biopsy specimens from the gastric antrum using immuohistochemical stain.The severe degree of gastritis was evaluated by histologic examination in each specimen using the criteria of Rauws.Results The pos i tive rates of Hp infection were90%,58%and50%in the perforation,bleeding of peptic ulcer and pyloristenosis respectively.The grade of Hp infection were3.4 ± 0.19,2.2 ± 0.17and2.6 ± 0 . 20respectively.Rauws scores were8.0 ± 0.31,5.1 ± 0.29,and5.8 ± 4.2respectively .The perforation of peptic ulcer has a more severe Hp infection(P<0.01)and gastritic change(P<0.05)than that ulcerative bleeding and pyloristenosis.Conclusion The perforation of peptic ulcer correlated with closely Hp infection,and radical cure of Hp can effectively prevent the ulcerative perforation.
出处
《岭南现代临床外科》
2003年第2期116-118,共3页
Lingnan Modern Clinics in Surgery
关键词
幽门螺杆菌
溃疡
穿孔
出血
幽门狭窄
Helicobacter pylori
Ulcer
Perforation
Hemorrhage
Pyloristenosis.
