摘要
本文依据近年来国内外相关文献资料,对有关PAMPA细胞模型自身及应用的发展进行了综述。介绍了平行人造膜通透性测定法(PAMPA)自身及其在药物吸收方面应用的热点和最新进展。通过文献研究发现PAMPA细胞模型不断优化与改良,近年来主要应用于化合物高通量筛选、处方设计等方面。而将PAMPA模型应用于国内药物吸收研究值得关注。
In this study,the parallel artificial membrane permeability assay(PAMPA) and the development of its application in absorption are introduced according to the pertinent literature.The PAMPA method and its advancement are discussed.After carefully investigated,the PAMPA method is found to be optimized continuously.In recent years,the PAMPA method has mainly been used in the aspects of high-flux screening and performulaion.It would be worthy to pay attention to the absorption study in domestic research.
出处
《中药与临床》
2011年第1期28-30,共3页
Pharmacy and Clinics of Chinese Materia Medica
关键词
平行人造膜通透性测定法
吸收
进展
Parallel artificial membrane permeability assay
absorption
development
