摘要
多种钠离子通道亚型在初级感觉神经元中的表达及动态调节,影响神经病理性疼痛的发生、发展及维持过程。SCN9A基因(编码Nav1.7)的多个位点突变被认为与人类多种可遗传的疼痛疾病密切相关。转基因技术和特异性敲除技术的应用发现,Nav1.3、Nav1.8和Nav1.9在神经病理性疼痛的发生和维持方面起到重要的作用。因此,研究电压依赖性钠离子通道在神经病理性疼痛中的作用,有利于揭示该种疾病的发生和维持机制,也可为开发新一代镇痛药物提供理论依据。
Voltage-gated sodium channels are critical for the generation and conduction of nerve impulses.Recent studies show that in primary sensory neurons,the expression and dynamic regulation of several sodium channel subtypes play important roles in neuropathic pain.A number of SCN9A(encoding Nav1.7) gene point mutations are related with human genetic pain disorders.Transgenic and specific knockout techniques have revealed that Nav1.3,Nav1.8,Nav1.9 are important for the development and maintenance of neuropathic pain condition.Specific blockers of these sodium channels have been demonstrated to be effective in alleviating allodynia and hyperalgesia.Here we reviewed the roles of sodium channels in neuropathic pain,which may be applicable for the development of new drugs with enhanced efficacy for neuropathic pain treatment.
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2011年第2期217-221,229,共6页
Journal of Zhejiang University(Medical Sciences)
基金
国家杰出青年基金资助项目(30725047)
国家自然科学基金资助项目(30701015)
