摘要
微小核糖核酸(microRNA,miRNA)是一类长度约为22个核苷酸的单链小分子核糖核酸,与肿瘤的发生、发展密切相关,癌组织miRNA表达谱与癌旁正常组织差异显著,具有癌组织特异性,是潜在的肿瘤标记物。文中就近年来miRNA与食管癌关系的研究做一综述,探讨miRNA在食管癌的检测、诊断、治疗以及预后判断上的可行性及其临床意义。
MicroRNAs(miRNA) are species of small noncoding single-stranded RNA with the lengths around 22 nucleotides.Growing evidences have indicated that miRNAs play an important role in tumorigenesis,and the miRNA expression profile in a tumor tissue is significantly different from adjacent normal tissues.Many cancers include esophageal cancer have specific miRNA expression profiles that can be used as a potential tumor markers.In this review,we summarized the latest research progress about miRNA and esophageal cancer,and discussed the possible use of miRNAs as important diagnostic and prognostic markers of esophageal cancer.
出处
《医学研究生学报》
CAS
2011年第6期646-650,共5页
Journal of Medical Postgraduates
基金
南京军区南京总医院科研基金(Z2008054)
关键词
微小核糖核酸
食管鳞状细胞癌
食管腺癌
肿瘤标记物
MicroRNA
Esophageal squamous cell carcinoma
Esophageal adenocarcinoma
Tumor marker
