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华蟾素辅助立体定向体部伽玛刀治疗原发性肝癌的临床研究 被引量:15

Clinical research of stereotactic conformal body γ-knife and cinobufacini on patients with hepatocellular carcinoma
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摘要 目的研究立体定向体部伽玛刀配合华蟾素注射液在原发性肝细胞癌综合治疗中的临床价值。方法选择诊断明确的60例原发性肝癌患者作为研究对象,将他们随机分为2组:对照组30例,给予立体定向体部伽玛刀治疗;联合组30例,在接受伽玛刀治疗的同时给予华蟾素注射液静滴,比较两组患者治疗后的临床疗效。结果治疗后联合组患者在疼痛缓解率、生活质量、生存时间、临床疗效等指标上均较对照组患者进一步改善和提高(P<0.05)。结论华蟾素能减轻放疗毒副反应,立体定向体部伽玛刀联合华蟾素能提高肝癌患者的临床疗效,不良反应轻,是一种安全有效的综合治疗方案。 Objective This study aims to investigate the clinical value of stereotactic conformal body gamma(γ)-knife combined with cinobufacini on patients with hepatocellular carcinoma.Methods 60 patients who were diagnosed as hepatocellular carcinoma were divided into two groups randomly.30 patients of the control group were treated by stereotactic conformal body γ-knife only,and 30 patients of joint group were treated by body γ-knife and cinobufacini together.Then the clinical effect of the joint group and control group was compared after different treatment.Results After treatment,the ratio of pain relief,quality of life,survival time and clinical effect in joint group were distinctly better than control group (P<0.05).Conclusions Cinobufacini can reduce adverse reaction of radiotherapy;Stereotactic conformal body γ-knife combined with cinobufacini can be an effective and safe treatment for patients with hepatocellular carcinoma.
机构地区 解放军第 解放军第
出处 《中华临床医师杂志(电子版)》 CAS 2011年第7期1901-1905,共5页 Chinese Journal of Clinicians(Electronic Edition)
关键词 肝肿瘤 放射外科手术 蟾蜍毒素 伽玛刀 Liver neoplasms Radiosurgery CINOBUFOTOXIN Gamma knife
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