摘要
目的检测c-FLIP与P53在胆囊癌和胆囊炎组织中的表达,比较c-FLIP和P53各自在胆囊癌和胆囊炎组织中的表达差异,探讨它们是否与肿瘤的生物学行为相关,以及两者之间表达的相互关系。方法采用免疫组化法检测c-FLIP和P53在49例胆囊癌标本和30例慢性胆囊炎标本中的表达,并对结果进行统计学分析。结果胆囊癌组织中c-FLIP和P53表达(85.71%和65.31%)显著高于胆囊炎组织(26.67%和26.67%)。c-FLIP和P53在胆囊癌组织中的表达与患者性别、胆囊癌的分化程度、TNM分期及有无淋巴结转移之间无显著关联。c-FLIP和P53在胆囊癌组织中表达有明显差异(χ2=5.06,P<0.05),但无显著联系(χ2=1.82,P>0.05)。结论 c-FLIP和突变型P53的过表达与胆囊癌的发生关系密切,可能都属于早期事件。c-FLIP与突变型P53在胆囊癌发生过程中的作用机制、途径可能不同。
Objective To detect the expression of c-FLIP and P53 in tissues of gallbladder carcinoma and cholecystitis.Compare the respective differences of expression of c-FLIP and P53 in tissues of gallbladder carcinoma and cholecystitis.To explore whether there are relations between the expressions of them and the biological behavior of tumor,and analyze the correlation between c-FLIP and P53.Methods The expression of c-FLIP and P53 in 49 cases of gallbladder carcinoma specimens and 30 cases of chronic cholecystitis specimens were detected by immunohistochemical method.The results were analyzed with the statistical analysis software.Results The positive expression rate of c-FLIP and P53 in tissues of gallbladder carcinoma(85.71%,65.31%)were significantly higher than that in tissues of cholecystitis(26.67%,26.67%).There were no statistical significances between the expression of c-FLIP or P53 in carcinoma of gallbladder and tumor TNM stage,differentiation grade,lymphatic metastasis,and sex.Paired data statistical analysis indicated that there was significant difference(χ2=5.06,P<0.05)and no remarkable correlation(χ2=1.82,P>0.05)between the expression of c-FLIP and P53 in tissues of gallbladder carcinoma.Conclusions The overexpression of c-FLIP and the mutant P53 gene may be the early events and play important roles in the initiation of gallbladder carcinoma.c-FLIP and mutant P53 have different mechanisms and pathways in the initiation of gallbladder carcinoma.
出处
《中华临床医师杂志（电子版）》
CAS
2011年第17期5003-5008,共6页
Chinese Journal of Clinicians(Electronic Edition)
