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ACE2基因:高血压防治新的靶点 被引量：8

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摘要 肾素-血管紧张素-醛固酮系统(renin-angiotensin-aldosterone system,RAAS)在调节水盐代谢、维持血容量与血管张力以及调控心血管、肾脏功能等方面起着极其重要的作用,是机体内调控血压稳定的最重要机制之一,其活性异常参与高血压病的发病过程[1-2]。新近发现的血管紧张素转换酶2(angiotensin converting enzyme2,ACE2)是RAAS中的关键调控酶[1]。
作者 金海燕 宋蓓 钟久昌
机构地区 上海交通大学医学院附属瑞金医院临床心理科与医学基因组学国家重点实验室 上海市高血压研究所上海市血管生物学重点实验室
出处 《中华临床医师杂志（电子版）》 CAS 2011年第17期5062-5065,共4页 Chinese Journal of Clinicians(Electronic Edition)
基金 国家自然科学基金(30973522&81170246) 上海市浦江人才计划项目(11PJ1408300)
关键词 高血压病 活性异常 ACE2 RAAS 基因 靶点
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献22

二级参考文献88

  • 1钟久昌,朱鼎良.血管紧张素转换酶2与高血压[J].高血压杂志,2005,13(11):682-686. 被引量：20
  • 2Krum H, Gilbert RE. Novel therapies blocking the reninangiotensin-aldosterone system in the management of hypertension and related disorders [ J ]. J Hypertens, 2007, 25 (1) :25 -35.
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共引文献60

同被引文献51

  • 1杜俊蓉,白波,余彦,汪程远,钱忠明.当归挥发油研究新进展[J].中国中药杂志,2005,30(18):1400-1406. 被引量：111
  • 2Oudit GY,Liu GC,Zhong J. Human recombinant ACE2 reduces the progression of diabetic nephropathy[J].Diabetes,2010.529-538.
  • 3Olivares-Reyes JA,Arellano-Plancarte A,Castillo-Hernandez JR. An-giotensinⅡand the development of insulin resistance:Implications for diabetes[J].Molecular and Cellular Endocrinology,2009.128-139.
  • 4Zimmet P,Alberti KG,Shaw J. Global and societal implications of the diabetes epidemic[J].Nature,2001.782-787.
  • 5Zhong JC,Guo D,Chen CB. Prevention of angiotensinⅡ-media-ted renal oxidative stress,inflammation,and fibrosis by angiotensin-converting enzyme 2[J].Hypertension,2011.314-322.
  • 6Dong B,Yu QT,Dai HY. Angiotensin-converting enzyme-2 over-expression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy[J].Journal of the American College of Cardiology,2012.739-747.
  • 7Henriksen EJ,Prasannarong M. The role of the renin-angiotensin sys-tem in the development of insulin resistance in skeletal muscle[J].Molecular and Cellular Endocrinology,2012.
  • 8Patel VB,Bodiga S,Basu R. Loss of angiotensin-converting en-zyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction:a critical role of the angiotensinⅡ/ AT1 receptor axis[J].Circulation Research,2012.1322-1335.
  • 9Santos RA,Ferreira AJ,Verano-Braga T. Angiotensin-converting enzyme 2,Angiotensin-(1-7)and Mas:new players of the Renin An-giotensin System[J].Journal of Endocrinology,2012.
  • 10Bindom SM,Lazartigues E. The sweeter side of ACE2:physiological evidence for a role in diabetes[J].Molecular and Cellular Endocrinology,2009.193-202.

引证文献8

二级引证文献27

中华临床医师杂志（电子版）
2011年 第17期

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