摘要
目的比较白介素-6(IL-6)和超敏C-反应蛋白(hs-CRP)与胰岛素抵抗(IR)的相关性。方法纳入154例一般健康人群,测定体重、身高、血压、空腹血浆葡萄糖(FPG)、血清胰岛素(Fins)、血脂、IL-6和hs-CRP等,计算体重指数(BMI)和IR指数(HOMA-IR),并以HOMA-IR上四分位为切点分为IR组与非IR组。结果 IR人群血清IL-6和hs-CRP水平较非IR人群明显升高(P<0.05)。Pearson相关分析显示,IL-6和hs-CRP均与HOMA-IR相关(r=0.58,r=0.48,P<0.05)。校正年龄、BMI后,IL-6仍然与HOMA-IR密切相关(r=0.14,P<0.05),而hs-CRP与HOMA-IR的相关性无统计学意义(r=0.06,P>0.05)。进一步作Logistic回归分析发现,高IL-6人群发生IR的风险较低IL-6人群增加2.46倍[OR(95%CI):2.46(1.48～3.39),P<0.05],而高hs-CRP人群发生IR的风险较低CRP人群仅增加1.82倍[OR(95%CI):1.82(1.14～2.67),P<0.05]。结论在一般健康人群中,与hs-CRP相比,IL-6是更好的IR预测指标。
Objective To compare the associations of Interleukin 6(IL-6) and high sensitive C-reactive protein(hs-CRP) with insulin resistance(IR) in general healthy subjects.Methods 154 general healthy subjects were recruited.Weight,height,blood pressure,fasting plasma glucose(FPG),fasting serum insulin(Fins),blood lipids,IL-6 and hs-CRP were measured.Body mass index(BMI) and HOMA index(HOMA-IR) was calculated.IR was defined as the upper quartile of HOMA-IR.Results Serum IL-6 and hs-CRP were significantly higher in subjects with IR compared with subjects without IR(P<0.05).Spearman correlation analysis showed that both IL-6 and hs-CRP positively correlated with HOMA-IR(r= 0.58,r=0.48,P<0.05).Partial correlation analysis with control of BMI showed that PEDF was positively correlated with hs-CRP.After adjustment for age,and BMI,IL-6 was still associated with HOMA-IR(r=0.14,P<0.05);However,the association between hs-CRP and HOMA-IR no longer existed.Moreover,Logistic regression analysis revealed that compared to the subjects with low IL-6,those with high IL-6 were 2.46 times more likely to exhibit IR;while compared to the subjects with low hs-CRP,those with high hs-CRP were just 1.82 times more likely to be exhibit IR.Conclusion compared with hs-CRP,IL-6 might be a better marker of IR in general healthy subjects.
出处
《四川医学》
CAS
2012年第11期1974-1976,共3页
Sichuan Medical Journal
关键词
白介素-6
超敏C-反应蛋白
胰岛素抵抗
Interleukin 6
high sensitive C-reactive protein
insulin resistance
