摘要
中药复方多成分、多靶点协同作用的药理作用机制研究是中药现代化和国际化的"瓶颈"之一。近年出现的网络生物学研究方法为中药复方药理作用机制系统研究提供重要而有效的新思路、新模式。本文介绍了网络生物学研究的数学基础、论述了网络生物学在中药药理作用机制研究中的可行性,并提出了网络生物学在中药药理作用机制方面的研究思路。网络生物学可望为中药药理作用机制研究奠定理论基础,指导中药复方药物的开发,更好地继承和发扬祖国中医药学理论。
The mechanism of synergetic effects of multi-components on multi-targets in traditional Chinese medicine(TCM) is one of the bottlenecks for TCM modernization and internationalization.Network biology approach was developed in recent years and provided an important and novel idea to study the pharmacological mechanism of TCM.This review introduced the mathematical basis of network biology,as well as the feasibility and research idea of using network biology to study the pharmacological mechanism of TCM.Network biology was expected to be further used for analyzing the pharmacological mechanism of TCM,guiding drug development of TCM,inheriting and carrying forward the fundamental principle of TCM.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2012年第2期146-151,共6页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81001614)
浙江省自然科学基金项目(Y2100317)
关键词
网络生物学
系统生物学
中药药理作用机制
network biology
systems biology
pharmacological mechanism of traditional Chinese medicine
