摘要
目的 :了解尿培养中产超广谱 β 内酰胺酶的肺炎克雷伯菌、大肠埃希菌的发生率和耐药性 ,为临床合理选择抗生素提供依据。方法 :用VITEK 32型全自动细菌分析系统进行细菌鉴定、药敏分析和ESBLs测定。结果 :在 87株大肠埃希菌、 6 3株肺炎克雷伯菌中ESBLs的检出率分别为 4 4 8%、 39 7% ,ESBLs产生株对头孢他啶、头孢噻肟的耐药性高达 96 9%～ 97 2 % ,较非ESBLs产生株高 94 9%。对氨基糖苷类、喹诺酮类、磺胺类的耐药性最高分别达到 80 5 %、 91 6 %、 92 5 % ,所有受试菌对亚胺培南均敏感。大肠埃希菌对阿米卡星耐药率较肺炎克雷伯菌低。结论 :治疗产超广谱 β 内酰胺酶菌引起的尿路感染 ,应选用亚胺培南和含 β 内酰胺酶抑制剂复合物以及根据药敏试验结果选用抗生素。
Objective:To determine the prevalence of strains producing ESBLs among Klebsiella pneumoniae and Escherichia coli, and investigate the antibiotic resistance of these strains. Methods:Producing ESBLs bacteria were detected using Vitek-32 system. Results: Among 87 strains of Escherichia coli, 63 strains of Klebsiella Pneumoniase. producing ESBLs bacteria accounted for 44.8%, 39.7%. The resistance rate of ESBLs-producing strains to ceftazidime, cefotaxime was 96.9%～97.2%, 94.9% higher than that of non-ESBLs-producing strains. ESBLs-producing strains had higher resistance rate to aminoglycosides, quinolones, sulfonamides (80.5%?91.6%?92.5% respectively). All tested strains However, were susceptible to imipenem. Conclusion:To deal with the ESBLs-producing strains, such antibiotics as imipenem,β-lactamase inhibitor combinations and others which are sensentive to such strains can be used.
出处
《湖北省卫生职工医学院学报》
2004年第2期67-69,共3页
Journal of Hubei Medical Staff College
