摘要
目的探讨血浆β2微球蛋白、血尿酸与老年H型高血压患者踝肱指数(ABI)的关系。方法154例伴有高同型半胱氨酸血症的原发性高血压患者,按ABI分为3组,0.4≤ABI<0.7的患者为1组(48例),0.7≤ABI<0.9的患者为2组(52例),0.9≤ABI<1.3的患者为3组(54例),以同期48例非高血压患者作为对照,各组均检测血浆β2微球蛋白、尿素氮、血肌酐、血尿酸、三酰甘油、胆固醇、低密度脂蛋白水平,并进行组间比较。结果 H型高血压患者血浆β2微球蛋白、血尿酸水平较对照组明显增高(P<0.05),随着ABI水平的升高,β2微球蛋白、血尿酸水平逐步下降。结论β2微球蛋白可以作为评价H型高血压患者动脉硬化的预测指标,尿酸增高可以加重H型高血压患者动脉硬化程度。
Objective To investigate the relationship of ankle brachial index( ABI) with plasma β2-microglobulin and uric acid( UA) in the elderly patients with H-type hypertension. Methods 154 elderly patients with primary hypertension complicated with hyperhomocysteinemia were divided into 3 groups according to the level of ABI. The patients with 0. 4≤ABI < 0.7 were enrolled in group 1( n = 48),the patients with 0. 7≤ABI < 0. 9 enrolled in group 2( n = 52),and the patients with 0. 9≤ABI < 1.3 enrolled in group 3( n = 54). 48 patients with normal blood pressure were enrolled as control. The plasma β2-microglobulin,urea nitrogen,serum creatinine,UA,glycerin trilaurate,cholesterol and low density lipoprotein were detected and compared between the groups. Results Compared with control group,the plasma level of β2-microglobulin and the serum level of UA in the elderly patients with H-type hypertension were significantly increased( P <0. 01). Plasma levels of β2-microglobulin and UA were negatively correlated with ABI. Conclusions Plasma β2microglobulin can be taken as a predictive index to assess the arteriosclerosis of elderly patients with H-type hypertension and the increase of purine trione will aggravate the degree of arteriosclerosis.
出处
《实用老年医学》
CAS
2013年第11期939-941,共3页
Practical Geriatrics
