摘要
柠檬酸是能量代谢的产物,只有在阻止正常代谢进行的情况下柠檬酸才可能大量积累。20世纪30年代人们已经初步掌握了黑曲霉(Aspergillus niger)柠檬酸的发酵条件并进行规模化生产,然而对柠檬酸积累机理的研究还不是很透彻,黑曲霉柠檬酸积累引起了众多研究者的关注。另外,一些新的生物技术如基因组学技术的应用也为黑曲霉柠檬酸代谢的深层研究提供了可能。综述了黑曲霉柠檬酸代谢过程中己糖的输送、糖酵解和能荷调节机制的研究进展。
Citric acid is regarded as a metabolite of energy metabolism,and its concentration will rise to appreciable amounts only under conditions of substantive metabolic imbalances.Citric acid fermentation conditions by Aspergillus niger were established during the 1930s.The biochemical mechanism of accumulating citric acid by A.niger is still attracting the interest of many researchers even though its commercial production by fermentation has been established for decades.Although extensive basic biochemical research has been carried out with A.niger,the mechanism of citric acid accumulation is not completely understood,while some new biological techniques such as genomics technology might provide the possibility for extensive research about the citric acid metabolism of A.niger.A review of physiological events that cause such intracellular conditions,with the special emphasis on the discussion of hexose transporting into cells and regulation of primary metabolism,predominantly of glycolytic flux and energy charger during the process,was presented.
出处
《湖北农业科学》
北大核心
2013年第7期1489-1492,共4页
Hubei Agricultural Sciences
基金
国家自然科学基金项目(30870107)
