摘要
目的比较不同发病部位结直肠癌患者的临床表现、病理学特征。方法采用Epidata软件建立大肠癌信息化数据库录入宁夏医科大学总医院2001年12月-2011年3月间收治的702例原发性结直肠癌住院患者临床资料,分析不同肿瘤部位患者的临床表现及肿瘤特征。结果本组资料近端结肠癌41.0%,远端结肠癌41.7%,直肠癌17.2%。不同发病部位结直肠癌患者的性别、年龄、城乡分布间的差异无统计学意义(P>0.05)。不同发病部位结直肠癌患者出现的食欲减退、贫血、腹痛、腹胀、血便、脓血便、便频、大便变细、肠梗阻等症状的差异有统计学意义(P均<0.05),不同发病部位结直肠癌患者出现的体重下降、腹泻、便秘、FOBT阳性、黏液便等症状的差异无统计学意义(P均>0.05)。近端结肠癌常出现腹痛、腹胀、食欲减退症状;远端结肠癌多见腹痛、血便、腹胀;直肠癌多见血便、便频、脓血便。不同发病部位结直肠癌间肿瘤浸润深度有差异(P=0.000),不同部位的结直肠肿瘤均浸及浆膜层最多。不同发病部位结直肠癌间肿瘤细胞分化程度差异有统计学意义(P<0.05),不同部位的结直肠癌均以中分化癌多见。淋巴组织增生在近端结肠癌最多(P=0.000)。淋巴、腹膜转移均在近端结肠癌最常见(P均<0.05)。结论不同发病部位结直肠癌的主要临床表现、分化程度、浸润深度、淋巴组织增生及转移途径不同,可为临床诊断及预后判断提供参考。
Objective To compare the features of colorectal cancer(CRC) at various affected sites and to increase the awareness of the clinical features.Methods The data of 702 cases with colorectal carcinoma were collected between Dec.2001 and Mar.2011.According to affected sites,information about clinical manifestation as well as information about tumor features were analyzed and compared.Results The lesions located in distal colon accounted for 41.7 % while those in proximal colon and rectum accounted for 41.0% and 17.2%,respectively.No significant differences were found in sex,age and the proportion of urban and rural among different affected sites.Abdominal pain,weight loss and abdominal distention were the most frequent symptoms in patients with proximal colon cancer.Abdominal pain,bloody stool,weight loss appeared frequently in patients with distal colon cancer while bloody stool,diarrhea and bloody purulent stool appeared frequently in patients with rectal cancer.The depth of invasion was significantly correlated with cancer onset site(P=0.000).There was significant difference among different affected sites in moderately and poorly differentiated cancer(P<0.05).The lymph node proliferation were significantly correlated with cancer onset site(P=0.000).Lymph node and peritoneum metastasis were significantly correlated with cancer onset site(P<0.05).Conclusion There were significant differences among patients with different affected sites of the colorectal cancer in clinical manifestation,the depth of invasion,differentiated degree,lymphoid proliferation,lymph node and peritoneum metastasis.
出处
《宁夏医科大学学报》
2013年第5期525-527,共3页
Journal of Ningxia Medical University
基金
宁夏自然科学基金(NZ11170)
关键词
结直肠癌
部位
临床表现
肿瘤特征
colorectal cancer
clinical manifestation
tumor features
