摘要
Objective To investigate the expression of cyclin E and p27kipl in bladder transitional cell carcinoma and its clinical significance. Methods cyclin E and p27kipl expressions were detected in 69 specimens by SP of immunohistochemistry. The results were analyzed in relation to the clinical data. Results The positive rates of cyclin Eexpression and p27kipl expression in bladder carcinoma were 42 % and 51 %, respectiely. cyclin Eexpression was positively related to the tumor grade, the higher the tumor grade, the higher the cyclin E positive expression; but there was no association between cyclin Epositive expression and tumor clinical stage. Significant correlation was found between p27kipl positive expression and tumor grade and clinical stage, the lower the p27kipl positive expression, the highter the tumor grade and clinical stage. In relapsing bladder carcinoma,both cyclin E and p27kipl positive expression decreased significantly. There was close correlation between cyclin E expression and p27kipl
Objective To investigate the expression of cyclin E and p27kipl in bladder transitional cell carcinoma and its clinical significance. Methods cyclin E and p27kipl expressions were detected in 69 specimens by SP of immunohistochemistry. The results were analyzed in relation to the clinical data. Results The positive rates of cyclin Eexpression and p27kipl expression in bladder carcinoma were 42 % and 51 %, respectiely. cyclin Eexpression was positively related to the tumor grade, the higher the tumor grade, the higher the cyclin E positive expression; but there was no association between cyclin Epositive expression and tumor clinical stage. Significant correlation was found between p27kipl positive expression and tumor grade and clinical stage, the lower the p27kipl positive expression, the highter the tumor grade and clinical stage. In relapsing bladder carcinoma,both cyclin E and p27kipl positive expression decreased significantly. There was close correlation between cyclin E expression and p27kipl expression and the correlation was statistically significant. Conclusion Cyclin E and p27kipl expressions may be important prognostic indicators and potentially useful for assessing tumor malignant extent. 10 refs.
出处
《外科研究与新技术》
2003年第2期114-114,共1页
Surgical Research and New Technique
