摘要
目的获得对碘具有良好吸附性的载体。方法使用反相悬浮交联法制备淀粉微球,对乳化过程中影响粒径分布的单因素进行考察;在交联过程中,以吸附量为指标,采用正交实验,确定最佳反应条件;用SSX-550扫描电镜、激光衍射粒度分析仪、傅立叶红外色谱仪、差示扫描量热器、热重分析仪等对微球的结构及外观进行考察和表征。结果最佳合成工艺条件为:可溶性淀粉、水、氢氧化钠的质量比为7:20:2;水相的总量为20g,油相的体积为160mL,乳化剂用量为8g,搅拌速度为500r·min-1,乳化时间20min,分散均匀后,加入4mL环氧氯丙烷,45℃水浴交联4h。获得的微球粒径在68μm左右,形状圆整。红外光谱和热分析证明,糊精在交联后结构和性质发生很大变化,大量羟基的存在和三维网格结构使产物仍保持强亲水性和一定的机械强度,在溶液中可以溶胀并吸附载药。结论制备的交联可溶性淀粉微球可以作为碘的载体,用于局部消炎和杀菌。
Objective To prepare hydrophilic but insoluble microspheres from water soluble starch, and optimize its preparation process by orthogonal experiments.Methods An inverse suspension polymerization method was utilized to synthesize crosslinked starch microspheres, factors influencing emulsification and crosslinking reaction were studied.Fourier-transformed infrared spectrometry, SEM, laser particle size analyser, differential scanning calorimetry and thermo-gravimetry were employed to characterize the structure and properties of the starch microspheres.Results When the starch-water-alkaliratio was 7:20:2(m:m:m), the amount of water was 20 g , oil 160 mL, emulsifier 8 g and the stirring rate 500 r·min-1, fine emulsions were formed after 20 min stirring.Then the crosslinker was added under 45 ℃, and the reaction was continued for 4h.The microspheres with diameter around 68μm, a narrow particle size distribution(PSD) and good spherical shape were obtained.Fourier-transformed infrared spectrometry and thermoanalysis technique proved that the structure and characteristics of starch changed dramatically after crosslinking.The existence of abundant hydroxyl groups ensured the hydrophilicity and good water absorption ability of crosslinked starch microspheres.Conclusion The crosslinked starch microspheres prepared can be used as a drug-carrier for iodine, which is usually used as a bactericide.
出处
《中国药剂学杂志（网络版）》
2009年第3期161-170,共10页
Chinese Journal of Pharmaceutics：Online Edition
关键词
药剂学
微球
反相悬浮交联法
可溶性淀粉
交联
吸附
碘
pharmaceutics
microspheres
inverse suspension polymerization method
soluble-starch
crosslinking
absorption
iodine
