摘要
目的考察影响阿奇霉素羟丙甲纤维素(HPMC)骨架缓释片体外释药的各种因素,为阿奇霉素骨架片的研制提供实验依据。方法选用HPMC为骨架材料,将水难溶性药物阿奇霉素制成缓释骨架片,通过测定体外释放度,考察HPMC的黏度及用量、辅料、释放介质pH值、制片压力、释放度测定装置及其转速对阿奇霉素骨架片体外释药速率的影响。结果HPMC黏度及用量、辅料、释放介质pH值、释放度测定装置及其转速对释药速率有显著影响,制片压力对释药速率影响不显著。结论选用适宜黏度及用量的HPMC,调节辅料中乳糖的用量,可制备具有理想释药行为的阿奇霉素骨架缓释片。
Objectives To investigate factors influencing in vitro release of azithromycin from hydroxypropylmethylcellulose(HPMC) matrix tablets.Methods Poorly solube drug azithromycin containing HPMC matrix tablets were prepared with wet granulation method,and effects of HPMC viscosity,HPMC content,adjuvant content,pH of release media,compression force,release apparatus and rotation speed of baskets on in vitro release of azithromycin from the matrix tablets were investigated by release experiments.Results The release rate of azithromycin from HPMC matrix tablets was mainly controlled by the viscosity and content of HPMC,properties of the adjuvants,pH of the release medium,release apparatus and rotation speed of basket.The influence of compression force on drug release was not significant.Conclusions Azithromycin sustained release tablets with ideal release behavior could be prepared by selecting HPMC with suitable viscosity,adjusting the content of HPMC and lactose.
出处
《中国药剂学杂志（网络版）》
2008年第5期227-233,共7页
Chinese Journal of Pharmaceutics：Online Edition
关键词
药剂学
骨架片
阿奇霉素
分光光度法
释药速率
羟丙甲纤维素
pharmaceutics
matrix tablet
spectrophotometry
azithromycin
release rate
hydroxypropylmethylcellulose
