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术后不同镇痛方式对胸外科肿瘤患者IL-2、IL-8和皮质醇的影响 被引量:5

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摘要 目的观察术后不同镇痛方式对胸外科肿瘤患者外周静脉血细胞因子白介素-2(IL-2)、IL-8及应激激素皮质醇(Cor)水平的影响。方法选择该院手术治疗的胸外科肿瘤患者91例作为究对象,按术后镇痛方式不同分为两组,A组45例采用自控硬膜外镇痛,B组46例采用自控静脉镇痛。测定放置镇痛泵前、术后24、48、72 h患者血清中IL-2、IL-8和Cor的表达水平,整体及按良、恶性肿瘤分层分析不同麻醉方式对相关指标表达影响。结果恶性肿瘤层:在术后48 h,B组血清IL-2、IL-8和Cor表达水平分别为(7.42±1.1)、(0.28±0.03)和(326±48),A组分别为(10.75±1.4)、(0.48±0.04)和(258±52),差异有统计学意义(P<0.05);术后72 h,B组血清IL-8和Cor表达水平分别为(0.25±0.03)和(224±35),A组分别为(0.43±0.05)和(296±37),差异有统计学意义(P<0.05)。结论术后自控硬膜外麻醉镇痛对恶性肿瘤患者机体产生的免疫抑制作用和应激反应均较小,较适合胸外科恶性肿瘤患者术后镇痛。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2014年第1期93-94,共2页 Chinese Journal of Gerontology
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  • 1张静,崔苏扬.术后镇痛与免疫[J].临床麻醉学杂志,2006,22(9):717-718. 被引量:65
  • 2Nagasaka H,Ohno S,Kobayashi K, et al.The effect of anesthetics on malignant tumor cells. Masui . 2009
  • 3Golubovic S,Golubovic V,Sotosek-Tokmadzic V,et al.The proposed mechanism of action during different pain management techniques on expression of cytolytic molecule perforin in patients after colorectal cancer surgery. Medical Hypotheses . 2011
  • 4Fuggetta MP,Di Francesco P,Falchetti R,et al.Effect of morphineon cell-mediated immune responses of human lymphocytes againstallogeneic malignant cells. Journal of Experimental and Clinical Cancer Research . 2005
  • 5Wang ZY,Wang CQ,Yang JJ,et al.Which has the least immunity depression during postoperative analgesia:morphine,tramadol,or tramadol with lornoxicam. Clinica Chimica Acta . 2006
  • 6Franchi S,Panerai AE,Sacerdote P.Buprenorphine ameliorates the effect of surgery on hypothalamus-pituitary-adrenal axis,natural killer cell ac-tivity and metastatic colonization in rats in comparison with morphine or fentanyl treatment. Brain Behavior and Immunity . 2007
  • 7Loose D,Van de Wiele C.The immune system and cancer. Cancer Biotherapy and Radiopharmaceuticals . 2009
  • 8Snyder GL,Greenberg S.Effect of anaesthetic technique and other perioperative factors on cancer recurrence. British Journal of Anaesthesia . 2010
  • 9Welden B,Gates G,Mallari R,et al.Effects of anesthetics and analgesics on natur al killer cell activity. American Association of Nurse Anesthetists Journal . 2009
  • 10Beilin B,Hoofien D,Poran R,et al.Comparison of two patient-controlled analgesia techniques on neuropsychological functioning in the immediate postoperative period. Journal of Clinical and Experimental Neuropsychology . 2008

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