摘要
肿瘤-睾丸抗原(cancer-testis antigen,CTA)是一类具有特异性表达模式的肿瘤相关抗原,是包含MAGE、NY-ESO-1等抗原肽的一个基因大家族。基于CTA在肿瘤患者体内可诱发肿瘤特异性免疫应答,CTA已成为肿瘤免疫治疗的重要候选分子。本文就CTA在乳腺癌中的表达情况,尤其在三阴性乳腺癌(triple negative breast cancer,TNBC)中的表达及临床意义作一综述,为制订乳腺癌免疫治疗策略提供新的概念和思考,CTA有望成为TNBC特异性免疫治疗的理想靶点。
The cancer-testis antigens(CTA) are an expanding family of tumor-associated antigens including MAGE and NY-ESO-1, which have specifi c expression patterns. Because of their ability to elicit autologous cellular immune responses in tumor patients, CTAs have been identified important candidates for cancer immunotherapy. This article reviews the expression of CTAs in breast cancer, especially the expression in the triple negative breast cancer(TNBC) and their clinical signifi cance. This provides the new concept and thinking for immunization strategies in breast cancer. CTA appears an ideal target for TNBC specific immunotherapy.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2014年第2期173-175,共3页
Cancer Research on Prevention and Treatment
基金
天津市卫生局资助项目(2011KZ08)
关键词
肿瘤-睾丸抗原
乳腺癌
免疫治疗
Cancer-testis antigen(CTA)
Breast cancer
Immunotherapy
