摘要
目的 评价急性脑梗死 2 4小时内不同时间段应用降纤酶治疗的临床效果和安全性。方法 2 6例急性脑梗死患者行弥散加权磁共振成像 (diffusion weightedimaging ,DWI)及磁共振血管成像 (magneticresonanceangiography ,MRA)检查确诊 ,按病程分为Ⅰ组 12例 (病程≤ 6小时 ) ,Ⅱ组 14例 (病程 7～ 2 4小时 ) ;两组接受降纤酶治疗 ;治疗后行MRA检查。结果 对两组间的血管再通率、治疗前后神经功能缺损评分 (NDS)、出血转化率进行比较均无统计学意义 (P >0 .0 5 )。结论 急性脑梗死患者在DWI与MRA检查提供切实可行的影像学资料情况下 ,降纤治疗时间窗可以延至 6小时以后 ,仍能取得较高血管再通率和较好的临床疗效。
Objective To evaluate the efficacy and safety of defibrase in patients with acute cerebral infarction at different time course within 24 hours.Methods Twenty-six cases of acute cerebral infarction diagnosed by DWI and MRA were divided into two groups(I and II) according to course,group I(n=12,within 6 h)and group II(n=14,from 6 h to 24 h).MRA was conducted after defibrase treatment.Results There were no significant differences in recanalization rate,nerve function deficit and hemorrhage incidence between group I and II(P>0.05).Conclusion Defibrase treatment time window can be prolonged to 6h,when the best clinical efficacy and higher recanalization can be achieved,according to the practical and feasible DWI and MRA for acute cerebral infarction patients.
出处
《中国综合临床》
北大核心
2004年第6期498-499,共2页
Clinical Medicine of China
关键词
急性脑梗死
降纤酶
磁共振血管成像
Acute cerebral infarction
Defibrase
Magnetic resonance angiography
