摘要
目的 探讨溃疡性结肠炎 (UC)患者血小板功能状态和组织因子途径抑制物 (TFPI)的变化。方法 使用TYXN 91智能血液聚集仪测定 47例UC患者和 3 0例对照组血小板聚集率(PAg) ,同时采用ELISA法检测血清P 选择素 (Ps) ,采用发色底物法测定血浆TFPI含量 ,并对其进行相关性分析。结果 活动期UC患者PAg明显高于缓解期和对照组 (P <0 .0 1) ,活动期和缓解期UC患者Ps和TFPI含量均高于对照组 (P <0 .0 1和P <0 .0 5 ) ,PAg与TFPI呈正相关 (γ =0 .62 3 ,P <0 .0 1) ,Ps与TFPI无明显相关性 (γ =0 .2 3 5 ,P >0 .0 5 )。结论 活动期UC患者体内存在血小板激活 ,在缓解期血小板活化程度仍增高 ;UC患者血浆TFPI含量升高 ,且PAg与TFPI在UC患者的血栓前状态中可能发挥着协同作用。
Objective To study the functional state of platelet and the variation of tissue factor pathway inhibitor (TFPI) in the patients with ulcerative colitis (UC).Methods Platelet aggregability (PAg) was detected by TYXN-91 intelligent blood aggregation and coagulation tester;P-selectin (Ps) was determined with ELISA and TFPI consistency was determined with chromogenic peptide substrate method in 47 patients with UC and 30 healthy controls.Results Increased PAg was detected in active UC compared with inactive UC and healthy controls(P<0.01).The levels of Ps and TFPI in the patients with UC were significant higher than those in the controls(P<0.01 and P<0.05).There was a positive correlation between PAg and TFPI(γ=0.623,P<0.01),but there was not correlation between Ps and TFPI(γ= 0.235, P>0.05).Conclusions Active UC is marked by increased platelet activation.The platelet activity was also increased in inactive UC.TFPI was increased in the patients with UC,PAg and TFPI play synergetic role in the prothrombotic state of the patients with UC.
出处
《临床内科杂志》
CAS
北大核心
2004年第6期405-406,共2页
Journal of Clinical Internal Medicine
