摘要
目的探讨利培酮、氯氮平及传统抗精神病药物氯丙嗪在治疗精神分裂症时对患者血糖的影响。方法 将符合CCMD-Ⅲ精神分裂症诊断标准的住院患者165名随机分为三组,分别服用上述三种药物,于服药前及服药后4周、12周餐后12小时取时静脉血进行血糖测定,所得数据经t检验及X2分析。结果服药初期(4周内)三组患者之间血糖无显著性差异(P>0.05);但在第12周时氯氮平组患者血糖升高率明显比利培酮组及氯丙嗪组高(P<0.05)。结论 氯氮平比利培酮及氯丙嗪引起患者血糖增高的危险性高;长期用药,特别是老年及有糖尿病家族史患者应定期进行血糖监测。
Objective To explore the different influence to blood sugar of risperidon,clozapin and chlorpromazine in the treatment of patients with schizophtenia. Methods 165 in - patient schizophrenics met the CCMD - Ⅲ are randomly assigned to risperidon, clozapine or chlorpromazine group. The vein blood sugars are tested 12 hours after taking the drug in the 0,4th week(p>0.05). But in the 12th week,the blood sugars in clozapine group are obviously higher than that in other two groups (p<0.05). Conclusion Clozapine has higher risk in inducing high blood sugar than risperidon and chlorpromazine. Patients taking clozapine especially for those who are senile or have positive diabetes family history should take blood test regularly to supervise the blood sugar level.
出处
《医学检验与临床》
2003年第1期11-12,共2页
Medical Laboratory Science and Clinics
关键词
血糖
利培酮
氯氮平
氯丙嗪
Blood sugar Risperidon,Clozapine Chlorpromazine
