摘要
本研究采用正负交变加速度旋转刺激法制备大鼠运动病模型，并用钙离子（Ｃａ２＋）超微结构定位法观察了运动病大鼠大脑皮质、小脑皮质和脑干前庭区神经细胞中的Ｃａ２＋变化。结果表明，运动病大鼠大脑皮质、小脑皮质和脑干前庭区神经细胞胞质基质、线粒体和内质网中Ｃａ２＋反应产物增多。提示运动病的发生与中枢神经细胞Ｃａ２＋内流有关。
In this research the model of rat motion sickness was developed by rotatory stimulation with alternative positive and negative acceleration. The changes of ultrastructural localization of calcium ions (Ca 2+ ) in rat brain were observed under EM. The results showed that the reaction products of Ca 2+ in cytoplasmic matrix, mitochondria and endoplasmic reticulum in neurons of cerebral cortex, cerebellar cortex and vestibular area of brain stem of rats with motion sickness were increased. This implies that the development of motion sickness is closely related to Ca 2+ inflow of nerve cells in central nervous system.
出处
《中国组织化学与细胞化学杂志》
CAS
CSCD
1998年第4期99-103,共5页
Chinese Journal of Histochemistry and Cytochemistry
基金
海军科研基金
关键词
实验性运动病
钙离子
前庭刺激
超微结构
大鼠
Experimental motion sickness
Calcium ions
Vestibular stimulation
Ultrastructural localization
Rat
